A new biphenyl from the stem bark of Garcinia macrantha A.C.Sm

Rifaldi; Edwin R. Sukandar; Arif Fadlan; Sri Fatmawati; Adi S. Purnomo; Johanis Wairata; Taslim Ersam

doi:10.1080/14786419.2023.2190113

A new biphenyl from the stem bark of Garcinia macrantha A.C.Sm

Rifaldi, Edwin R. Sukandar, Arif Fadlan, Sri Fatmawati, Adi S. Purnomo, Johanis Wairata, Taslim Ersam^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

In our continuation of exploring antidiabetic agents from Garcinia species, we found that the methanolic extract of G. macrantha A.C.Sm. exhibited considerable α-glucosidase inhibition of 58.20 ± 0.37% in sucrose substrate and 39.86 ± 2.07% in maltose substrate at 100 μg/mL. Phytochemical investigation on the extract revealed the presence of a new biphenyl, macrabiphenyl A, which was successfully elucidated by means of spectroscopic methods (HRESIMS and 1D and 2D NMR). The α-glucosidase inhibitory evaluation indicated that the new compound was weakly active against the enzyme.

Original language	English
Pages (from-to)	2697-2702
Number of pages	6
Journal	Natural Product Research
Volume	38
Issue number	15
DOIs	https://doi.org/10.1080/14786419.2023.2190113
Publication status	Published - 2024

Keywords

Clusiaceae
Garcinia macranthaA.C.Sm
antidiabetic
antioxidant
biphenyl

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10.1080/14786419.2023.2190113

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abstract = "In our continuation of exploring antidiabetic agents from Garcinia species, we found that the methanolic extract of G. macrantha A.C.Sm. exhibited considerable α-glucosidase inhibition of 58.20 ± 0.37% in sucrose substrate and 39.86 ± 2.07% in maltose substrate at 100 μg/mL. Phytochemical investigation on the extract revealed the presence of a new biphenyl, macrabiphenyl A, which was successfully elucidated by means of spectroscopic methods (HRESIMS and 1D and 2D NMR). The α-glucosidase inhibitory evaluation indicated that the new compound was weakly active against the enzyme.",

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AU - Rifaldi,

AU - Sukandar, Edwin R.

AU - Fadlan, Arif

AU - Fatmawati, Sri

AU - Purnomo, Adi S.

AU - Wairata, Johanis

AU - Ersam, Taslim

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AB - In our continuation of exploring antidiabetic agents from Garcinia species, we found that the methanolic extract of G. macrantha A.C.Sm. exhibited considerable α-glucosidase inhibition of 58.20 ± 0.37% in sucrose substrate and 39.86 ± 2.07% in maltose substrate at 100 μg/mL. Phytochemical investigation on the extract revealed the presence of a new biphenyl, macrabiphenyl A, which was successfully elucidated by means of spectroscopic methods (HRESIMS and 1D and 2D NMR). The α-glucosidase inhibitory evaluation indicated that the new compound was weakly active against the enzyme.

KW - Clusiaceae

KW - Garcinia macranthaA.C.Sm

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A new biphenyl from the stem bark of Garcinia macrantha A.C.Sm

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Keywords

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