TY - JOUR
T1 - A novel selective and sensitive electrochemical sensor for insulin detection
AU - Zulkarnain,
AU - Suprapto,
AU - Ersam, Taslim
AU - Kurniawan, Fredy
N1 - Publisher Copyright:
© 2016 Institute of Advanced Engineering and Science. All rights reserved.
PY - 2016/9
Y1 - 2016/9
N2 - A novel selective and sensitive electrochemical sensor for insulin detection has been fabricated and investigated. The electrochemical sensor was made from a mixture of silica gel, chitosan and nickel hydroxide (Ni(OH)2) nanoparticles, which was mounted on a silver wire and covered by a glass tube (silica gel/chitosan/Ni(OH)2 nanoparticles paste electrode). The sensor was characterized using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The anodic and cathodic currents of the silica gel/chitosan paste electrode with Ni(OH)2 are 580 μA and -750 μA, respectively. Without Ni(OH)2, however, the currents are 150 μA and -250 μA, respectively. The sensitivity and limit of detection of the silica gel/chitosan/Ni(OH)2 nanoparticle paste electrode for insulin detection are 5573 × 105 pA/pMcm2 and 0.25 pM, respectively. The sensor also shows good reproducibility of measurement for 35 days with an RSD of 0.29%. The fabricated electrodes also show good reproducibility, with an RSD of 1.39%.
AB - A novel selective and sensitive electrochemical sensor for insulin detection has been fabricated and investigated. The electrochemical sensor was made from a mixture of silica gel, chitosan and nickel hydroxide (Ni(OH)2) nanoparticles, which was mounted on a silver wire and covered by a glass tube (silica gel/chitosan/Ni(OH)2 nanoparticles paste electrode). The sensor was characterized using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The anodic and cathodic currents of the silica gel/chitosan paste electrode with Ni(OH)2 are 580 μA and -750 μA, respectively. Without Ni(OH)2, however, the currents are 150 μA and -250 μA, respectively. The sensitivity and limit of detection of the silica gel/chitosan/Ni(OH)2 nanoparticle paste electrode for insulin detection are 5573 × 105 pA/pMcm2 and 0.25 pM, respectively. The sensor also shows good reproducibility of measurement for 35 days with an RSD of 0.29%. The fabricated electrodes also show good reproducibility, with an RSD of 1.39%.
KW - Chitosan
KW - Insulin
KW - Nickel hydroxide nanoparticles
KW - Silica gel
UR - http://www.scopus.com/inward/record.url?scp=85014304997&partnerID=8YFLogxK
U2 - 10.11591/ijeecs.v3.i2.pp496-502
DO - 10.11591/ijeecs.v3.i2.pp496-502
M3 - Article
AN - SCOPUS:85014304997
SN - 2502-4752
VL - 3
SP - 496
EP - 502
JO - Indonesian Journal of Electrical Engineering and Computer Science
JF - Indonesian Journal of Electrical Engineering and Computer Science
IS - 3
ER -