A novel selective and sensitive electrochemical sensor for insulin detection

Zulkarnain; Taslim Ersam; Fredy Kurniawan

doi:10.11591/ijeecs.v3.i2.pp496-502

A novel selective and sensitive electrochemical sensor for insulin detection

Zulkarnain
, Suprapto
, Taslim Ersam
, Fredy Kurniawan^*

^*Corresponding author for this work

Institut Teknologi Sepuluh Nopember

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

A novel selective and sensitive electrochemical sensor for insulin detection has been fabricated and investigated. The electrochemical sensor was made from a mixture of silica gel, chitosan and nickel hydroxide (Ni(OH)₂) nanoparticles, which was mounted on a silver wire and covered by a glass tube (silica gel/chitosan/Ni(OH)₂ nanoparticles paste electrode). The sensor was characterized using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The anodic and cathodic currents of the silica gel/chitosan paste electrode with Ni(OH)₂ are 580 μA and -750 μA, respectively. Without Ni(OH)₂, however, the currents are 150 μA and -250 μA, respectively. The sensitivity and limit of detection of the silica gel/chitosan/Ni(OH)₂ nanoparticle paste electrode for insulin detection are 5573 × 10⁵ pA/pMcm² and 0.25 pM, respectively. The sensor also shows good reproducibility of measurement for 35 days with an RSD of 0.29%. The fabricated electrodes also show good reproducibility, with an RSD of 1.39%.

Original language	English
Pages (from-to)	496-502
Number of pages	7
Journal	Indonesian Journal of Electrical Engineering and Computer Science
Volume	3
Issue number	3
DOIs	https://doi.org/10.11591/ijeecs.v3.i2.pp496-502
Publication status	Published - Sept 2016

Keywords

Chitosan
Insulin
Nickel hydroxide nanoparticles
Silica gel

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10.11591/ijeecs.v3.i2.pp496-502

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title = "A novel selective and sensitive electrochemical sensor for insulin detection",

abstract = "A novel selective and sensitive electrochemical sensor for insulin detection has been fabricated and investigated. The electrochemical sensor was made from a mixture of silica gel, chitosan and nickel hydroxide (Ni(OH)2) nanoparticles, which was mounted on a silver wire and covered by a glass tube (silica gel/chitosan/Ni(OH)2 nanoparticles paste electrode). The sensor was characterized using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The anodic and cathodic currents of the silica gel/chitosan paste electrode with Ni(OH)2 are 580 μA and -750 μA, respectively. Without Ni(OH)2, however, the currents are 150 μA and -250 μA, respectively. The sensitivity and limit of detection of the silica gel/chitosan/Ni(OH)2 nanoparticle paste electrode for insulin detection are 5573 × 105 pA/pMcm2 and 0.25 pM, respectively. The sensor also shows good reproducibility of measurement for 35 days with an RSD of 0.29\%. The fabricated electrodes also show good reproducibility, with an RSD of 1.39\%.",

keywords = "Chitosan, Insulin, Nickel hydroxide nanoparticles, Silica gel",

author = "Zulkarnain and Suprapto and Taslim Ersam and Fredy Kurniawan",

year = "2016",

month = sep,

doi = "10.11591/ijeecs.v3.i2.pp496-502",

language = "English",

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journal = "Indonesian Journal of Electrical Engineering and Computer Science",

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T1 - A novel selective and sensitive electrochemical sensor for insulin detection

AU - Zulkarnain,

AU - Suprapto,

AU - Ersam, Taslim

AU - Kurniawan, Fredy

PY - 2016/9

Y1 - 2016/9

N2 - A novel selective and sensitive electrochemical sensor for insulin detection has been fabricated and investigated. The electrochemical sensor was made from a mixture of silica gel, chitosan and nickel hydroxide (Ni(OH)2) nanoparticles, which was mounted on a silver wire and covered by a glass tube (silica gel/chitosan/Ni(OH)2 nanoparticles paste electrode). The sensor was characterized using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The anodic and cathodic currents of the silica gel/chitosan paste electrode with Ni(OH)2 are 580 μA and -750 μA, respectively. Without Ni(OH)2, however, the currents are 150 μA and -250 μA, respectively. The sensitivity and limit of detection of the silica gel/chitosan/Ni(OH)2 nanoparticle paste electrode for insulin detection are 5573 × 105 pA/pMcm2 and 0.25 pM, respectively. The sensor also shows good reproducibility of measurement for 35 days with an RSD of 0.29%. The fabricated electrodes also show good reproducibility, with an RSD of 1.39%.

AB - A novel selective and sensitive electrochemical sensor for insulin detection has been fabricated and investigated. The electrochemical sensor was made from a mixture of silica gel, chitosan and nickel hydroxide (Ni(OH)2) nanoparticles, which was mounted on a silver wire and covered by a glass tube (silica gel/chitosan/Ni(OH)2 nanoparticles paste electrode). The sensor was characterized using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The anodic and cathodic currents of the silica gel/chitosan paste electrode with Ni(OH)2 are 580 μA and -750 μA, respectively. Without Ni(OH)2, however, the currents are 150 μA and -250 μA, respectively. The sensitivity and limit of detection of the silica gel/chitosan/Ni(OH)2 nanoparticle paste electrode for insulin detection are 5573 × 105 pA/pMcm2 and 0.25 pM, respectively. The sensor also shows good reproducibility of measurement for 35 days with an RSD of 0.29%. The fabricated electrodes also show good reproducibility, with an RSD of 1.39%.

KW - Chitosan

KW - Insulin

KW - Nickel hydroxide nanoparticles

KW - Silica gel

UR - https://www.scopus.com/pages/publications/85014304997

U2 - 10.11591/ijeecs.v3.i2.pp496-502

DO - 10.11591/ijeecs.v3.i2.pp496-502

M3 - Article

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VL - 3

SP - 496

EP - 502

JO - Indonesian Journal of Electrical Engineering and Computer Science

JF - Indonesian Journal of Electrical Engineering and Computer Science

IS - 3

ER -

A novel selective and sensitive electrochemical sensor for insulin detection

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Keywords

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