Analysis of SELDI-TOF-MS using ε-support vector regression for ovarian cancer identification

Isye Arieshanti, Yudhi Purwananto

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

The analysis of protein expression profile using SELDI-TOF-MS can assist early detection of ovarian cancer. The chance to save patient’s life is greater when ovarian cancer is detected at an early stage. However, the analysis of protein expression profile is challenging because it has very high dimensional features and noisy characteristic. In order to tackle these limitations, the ε-Support Vector Regression model to identify ovarian cancer is proposed. We can show that the performance of the model to discriminate the protein expression profile with cancer disease from the normal ones can reach accuracy 99%, specificity 99% and sensitivity 100%. This result shows that the model is promising for SELDI-TOFMS analysis in Ovarian Cancer identification.

Original languageEnglish
Title of host publicationThe 15th International Conference on Biomedical Engineering, ICBME 2013
EditorsJames Goh
PublisherSpringer Verlag
Pages207-210
Number of pages4
ISBN (Electronic)9783319029122
DOIs
Publication statusPublished - 2014
Event15th International Conference on Biomedical Engineering, ICBME 2013 - Singapore, Singapore
Duration: 4 Dec 20137 Dec 2013

Publication series

NameIFMBE Proceedings
Volume43
ISSN (Print)1680-0737

Conference

Conference15th International Conference on Biomedical Engineering, ICBME 2013
Country/TerritorySingapore
CitySingapore
Period4/12/137/12/13

Keywords

  • Ovarian Cancer
  • SELDI-TOF-MS
  • Support Vector Regression

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