Analytical applications of electrodes modified by gold nanoparticles: Dopamine detection

Fredy Kurniawan, Vessela Tsakova, Vladimir M. Mirsky

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30 Citations (Scopus)


Dopamine oxidation was studied on modified gold (nano-Au) electrodes obtained by Layer-byLiayer deposition of gold nanoparticles and polyacrylic acid. A gradual loss of electrochemical activity for the dopamine oxidation reaction is observed at pH 7. Simultaneous SPR spectroscopy and cyclic voltammetry indicate the formation of an adsorbed layer on the electrode surface at this pH value. Investigations, performed through electrochemical and SPR measurements at pH 4, give evidence for a reversible process. At this pH value both dopamine oxidation and reduction current peaks show linear dependence on the dopamine concentration and may be used for analytical applications. The use of the nano-Au electrode allows resolving the peaks corresponding to ascorbic acid and to dopamine oxidation by 240 mV thus providing a high selectively for dopamine detection in the presence of ascorbic acid. The detection limit of this electrode for dopamine is below 4 μ,M in the presence of 1 mM ascorbic acid. The sensitivity normalized to the macroscopic electrode surface is about 10 mA • cm -2 mM -1 at sweep rate of 10 V/s.

Original languageEnglish
Pages (from-to)2407-2412
Number of pages6
JournalJournal of Nanoscience and Nanotechnology
Issue number4
Publication statusPublished - Apr 2009
Externally publishedYes


  • Ascorbic acid
  • Dopamine
  • Electrochemical detection
  • Gold nanoparticles
  • Surface plasmon resonance


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