Antibacterial and in vivo Antiplasmodial Activities from Garcinia lasoar

Cycloartane type-triterpenoid was isolated from ethyl acetate of Garcinia lasoar stem bark extract. The structure was elucidated by extensive IR, ¹H and ¹³CNMR techniques as 3-acetyl-3-oxo-cycloart-24-en-26-oic acid (OC). Antibacterial activities of extract and OC were also evaluated for Staphylococus aureus and Escherichia coli with chloramphenicol and ampicillin as positive control. The extract and OC showed antibacterial activities against S.aureus with IC₅₀ values of 32.36 μg/mL and 0.0005 μM, respectively. The in vivo antiplasmodial activity of stem bark extract also analysis use four groups of Mus musculus were infected by Plasmodiumberghei. The animal treated with extract showed suppression of parasitemia to 62.72±0.01% compared with the P. berghei infected-mice (negative control) with ED50 value of 68.98 mg/kg BW. The dose of extract in 200 mg/kg BW was more potential to reduce parasitemia of infected mice with P.berghei. The ethyl acetate extract of the stem bark G.lasoar and OC have antibacterial and antiplasmodial properties therefore, investigation is necessary to evaluate their mechanism of action.