Antihyperlipidemic and anti-obesity effects of the methanolic extract of parijoto (Medinilla speciosa)

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3 Citations (Scopus)

Abstract

Parijoto (Medinilla speciosa) is an endemic plant in Indonesia that was generally consumed by pregnant women and used as diarrhea and cholesterol drugs. The parijoto fruits are purplish red, where it is indicated that parijoto fruits contain anthocyanins i.e., water-soluble pigments in the plant, was found in most fruits, petals, and leaves. Anthocyanins belonging to the flavonoids compound family have been suggested to reduce certain cancers, coronary heart diseases, oxidative stress and other age-related diseases. This study was aimed to determine the effects of methanolic extract of parijoto (M. speciosa) on triglycerides level and obesity in hyperlipidemic rats. A pre-test and post-test randomized control group design were used in this study. Rats were divided into five groups: normal rats, hyperlipidemic rats, hyperlipidemic rats were given the methanolic extract of parijoto (M. speciosa) 500 mg·kg-1, 1 000 mg·kg-1, and 1 500 mg·kg-1 body weight. Blood was collected when rats are suffering from hyperlipidemia and after the 30 d treatment of methanolic extract of parijoto (M. speciosa). Rats were sacrificed after the 30 d treatment. The serum level of triglycerides was determined and the increase in body weight was measured weekly. Results showed that giving of methanolic extract of parijoto (M. speciosa) in hyperlipidemic rats reduced the triglycerides levels significantly (p < 0.01), the increase of body weight until 34 % and the adipose tissue in the peritoneum of hyperlipidemic rats.

Original languageEnglish
Title of host publicationInventing Prosperous Future through Biological Research and Tropical Biodiversity Management
Subtitle of host publicationProceedings of the 5th International Conference on Biological Science
EditorsZuliyati Rohmah, Lisna Hidayati, Tuty Arisuryanti, Maryani, Ganies Riza Aristya
PublisherAmerican Institute of Physics Inc.
ISBN (Print)9780735417182
DOIs
Publication statusPublished - 15 Aug 2018
Event5th International Conference on Biological Science: Inventing Prosperous Future through Biological Research and Tropical Biodiversity Management, ICBS 2017 - Yogyakarta, Indonesia
Duration: 15 Sept 201716 Sept 2017

Publication series

NameAIP Conference Proceedings
Volume2002
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference5th International Conference on Biological Science: Inventing Prosperous Future through Biological Research and Tropical Biodiversity Management, ICBS 2017
Country/TerritoryIndonesia
CityYogyakarta
Period15/09/1716/09/17

Keywords

  • hyperlipidemia
  • obesity
  • parijoto
  • triglycerides

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