Antihyperlipidemic and anti-obesity effects of the methanolic extract of parijoto (Medinilla speciosa)

Noor Nailis Sa'Adah; Awik Puji Dyah Nurhayati; Kristanti Indah Purwani

doi:10.1063/1.5050142

Antihyperlipidemic and anti-obesity effects of the methanolic extract of parijoto (Medinilla speciosa)

Noor Nailis Sa'Adah^*
, Awik Puji Dyah Nurhayati
, Kristanti Indah Purwani

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

4 Citations (Scopus)

Abstract

Parijoto (Medinilla speciosa) is an endemic plant in Indonesia that was generally consumed by pregnant women and used as diarrhea and cholesterol drugs. The parijoto fruits are purplish red, where it is indicated that parijoto fruits contain anthocyanins i.e., water-soluble pigments in the plant, was found in most fruits, petals, and leaves. Anthocyanins belonging to the flavonoids compound family have been suggested to reduce certain cancers, coronary heart diseases, oxidative stress and other age-related diseases. This study was aimed to determine the effects of methanolic extract of parijoto (M. speciosa) on triglycerides level and obesity in hyperlipidemic rats. A pre-test and post-test randomized control group design were used in this study. Rats were divided into five groups: normal rats, hyperlipidemic rats, hyperlipidemic rats were given the methanolic extract of parijoto (M. speciosa) 500 mg·kg^-1, 1 000 mg·kg^-1, and 1 500 mg·kg^-1 body weight. Blood was collected when rats are suffering from hyperlipidemia and after the 30 d treatment of methanolic extract of parijoto (M. speciosa). Rats were sacrificed after the 30 d treatment. The serum level of triglycerides was determined and the increase in body weight was measured weekly. Results showed that giving of methanolic extract of parijoto (M. speciosa) in hyperlipidemic rats reduced the triglycerides levels significantly (p < 0.01), the increase of body weight until 34 % and the adipose tissue in the peritoneum of hyperlipidemic rats.

Original language	English
Title of host publication	Inventing Prosperous Future through Biological Research and Tropical Biodiversity Management
Subtitle of host publication	Proceedings of the 5th International Conference on Biological Science
Editors	Zuliyati Rohmah, Lisna Hidayati, Tuty Arisuryanti, Maryani, Ganies Riza Aristya
Publisher	American Institute of Physics Inc.
ISBN (Print)	9780735417182
DOIs	https://doi.org/10.1063/1.5050142
Publication status	Published - 15 Aug 2018
Event	5th International Conference on Biological Science: Inventing Prosperous Future through Biological Research and Tropical Biodiversity Management, ICBS 2017 - Yogyakarta, Indonesia Duration: 15 Sept 2017 → 16 Sept 2017

Publication series

Name	AIP Conference Proceedings
Volume	2002
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Conference

Conference	5th International Conference on Biological Science: Inventing Prosperous Future through Biological Research and Tropical Biodiversity Management, ICBS 2017
Country/Territory	Indonesia
City	Yogyakarta
Period	15/09/17 → 16/09/17

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

hyperlipidemia
obesity
parijoto
triglycerides

Access to Document

10.1063/1.5050142

Cite this

Sa'Adah, N. N., Nurhayati, A. P. D., & Purwani, K. I. (2018). Antihyperlipidemic and anti-obesity effects of the methanolic extract of parijoto (Medinilla speciosa). In Z. Rohmah, L. Hidayati, T. Arisuryanti, Maryani, & G. R. Aristya (Eds.), Inventing Prosperous Future through Biological Research and Tropical Biodiversity Management: Proceedings of the 5th International Conference on Biological Science Article 020046 (AIP Conference Proceedings; Vol. 2002). American Institute of Physics Inc.. https://doi.org/10.1063/1.5050142

Sa'Adah, Noor Nailis ; Nurhayati, Awik Puji Dyah ; Purwani, Kristanti Indah. / Antihyperlipidemic and anti-obesity effects of the methanolic extract of parijoto (Medinilla speciosa). Inventing Prosperous Future through Biological Research and Tropical Biodiversity Management: Proceedings of the 5th International Conference on Biological Science. editor / Zuliyati Rohmah ; Lisna Hidayati ; Tuty Arisuryanti ; Maryani ; Ganies Riza Aristya. American Institute of Physics Inc., 2018. (AIP Conference Proceedings).

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title = "Antihyperlipidemic and anti-obesity effects of the methanolic extract of parijoto (Medinilla speciosa)",

abstract = "Parijoto (Medinilla speciosa) is an endemic plant in Indonesia that was generally consumed by pregnant women and used as diarrhea and cholesterol drugs. The parijoto fruits are purplish red, where it is indicated that parijoto fruits contain anthocyanins i.e., water-soluble pigments in the plant, was found in most fruits, petals, and leaves. Anthocyanins belonging to the flavonoids compound family have been suggested to reduce certain cancers, coronary heart diseases, oxidative stress and other age-related diseases. This study was aimed to determine the effects of methanolic extract of parijoto (M. speciosa) on triglycerides level and obesity in hyperlipidemic rats. A pre-test and post-test randomized control group design were used in this study. Rats were divided into five groups: normal rats, hyperlipidemic rats, hyperlipidemic rats were given the methanolic extract of parijoto (M. speciosa) 500 mg·kg-1, 1 000 mg·kg-1, and 1 500 mg·kg-1 body weight. Blood was collected when rats are suffering from hyperlipidemia and after the 30 d treatment of methanolic extract of parijoto (M. speciosa). Rats were sacrificed after the 30 d treatment. The serum level of triglycerides was determined and the increase in body weight was measured weekly. Results showed that giving of methanolic extract of parijoto (M. speciosa) in hyperlipidemic rats reduced the triglycerides levels significantly (p < 0.01), the increase of body weight until 34 \% and the adipose tissue in the peritoneum of hyperlipidemic rats.",

keywords = "hyperlipidemia, obesity, parijoto, triglycerides",

author = "Sa'Adah, \{Noor Nailis\} and Nurhayati, \{Awik Puji Dyah\} and Purwani, \{Kristanti Indah\}",

note = "Publisher Copyright: {\textcopyright} 2018 Author(s).; 5th International Conference on Biological Science: Inventing Prosperous Future through Biological Research and Tropical Biodiversity Management, ICBS 2017 ; Conference date: 15-09-2017 Through 16-09-2017",

year = "2018",

month = aug,

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doi = "10.1063/1.5050142",

language = "English",

isbn = "9780735417182",

series = "AIP Conference Proceedings",

publisher = "American Institute of Physics Inc.",

editor = "Zuliyati Rohmah and Lisna Hidayati and Tuty Arisuryanti and Maryani and Aristya, \{Ganies Riza\}",

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Sa'Adah, NN , Nurhayati, APD & Purwani, KI 2018, Antihyperlipidemic and anti-obesity effects of the methanolic extract of parijoto (Medinilla speciosa). in Z Rohmah, L Hidayati, T Arisuryanti, Maryani & GR Aristya (eds), Inventing Prosperous Future through Biological Research and Tropical Biodiversity Management: Proceedings of the 5th International Conference on Biological Science., 020046, AIP Conference Proceedings, vol. 2002, American Institute of Physics Inc., 5th International Conference on Biological Science: Inventing Prosperous Future through Biological Research and Tropical Biodiversity Management, ICBS 2017, Yogyakarta, Indonesia, 15/09/17. https://doi.org/10.1063/1.5050142

Antihyperlipidemic and anti-obesity effects of the methanolic extract of parijoto (Medinilla speciosa). / Sa'Adah, Noor Nailis ; Nurhayati, Awik Puji Dyah ; Purwani, Kristanti Indah.
Inventing Prosperous Future through Biological Research and Tropical Biodiversity Management: Proceedings of the 5th International Conference on Biological Science. ed. / Zuliyati Rohmah; Lisna Hidayati; Tuty Arisuryanti; Maryani; Ganies Riza Aristya. American Institute of Physics Inc., 2018. 020046 (AIP Conference Proceedings; Vol. 2002).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Antihyperlipidemic and anti-obesity effects of the methanolic extract of parijoto (Medinilla speciosa)

AU - Sa'Adah, Noor Nailis

AU - Nurhayati, Awik Puji Dyah

AU - Purwani, Kristanti Indah

PY - 2018/8/15

Y1 - 2018/8/15

N2 - Parijoto (Medinilla speciosa) is an endemic plant in Indonesia that was generally consumed by pregnant women and used as diarrhea and cholesterol drugs. The parijoto fruits are purplish red, where it is indicated that parijoto fruits contain anthocyanins i.e., water-soluble pigments in the plant, was found in most fruits, petals, and leaves. Anthocyanins belonging to the flavonoids compound family have been suggested to reduce certain cancers, coronary heart diseases, oxidative stress and other age-related diseases. This study was aimed to determine the effects of methanolic extract of parijoto (M. speciosa) on triglycerides level and obesity in hyperlipidemic rats. A pre-test and post-test randomized control group design were used in this study. Rats were divided into five groups: normal rats, hyperlipidemic rats, hyperlipidemic rats were given the methanolic extract of parijoto (M. speciosa) 500 mg·kg-1, 1 000 mg·kg-1, and 1 500 mg·kg-1 body weight. Blood was collected when rats are suffering from hyperlipidemia and after the 30 d treatment of methanolic extract of parijoto (M. speciosa). Rats were sacrificed after the 30 d treatment. The serum level of triglycerides was determined and the increase in body weight was measured weekly. Results showed that giving of methanolic extract of parijoto (M. speciosa) in hyperlipidemic rats reduced the triglycerides levels significantly (p < 0.01), the increase of body weight until 34 % and the adipose tissue in the peritoneum of hyperlipidemic rats.

AB - Parijoto (Medinilla speciosa) is an endemic plant in Indonesia that was generally consumed by pregnant women and used as diarrhea and cholesterol drugs. The parijoto fruits are purplish red, where it is indicated that parijoto fruits contain anthocyanins i.e., water-soluble pigments in the plant, was found in most fruits, petals, and leaves. Anthocyanins belonging to the flavonoids compound family have been suggested to reduce certain cancers, coronary heart diseases, oxidative stress and other age-related diseases. This study was aimed to determine the effects of methanolic extract of parijoto (M. speciosa) on triglycerides level and obesity in hyperlipidemic rats. A pre-test and post-test randomized control group design were used in this study. Rats were divided into five groups: normal rats, hyperlipidemic rats, hyperlipidemic rats were given the methanolic extract of parijoto (M. speciosa) 500 mg·kg-1, 1 000 mg·kg-1, and 1 500 mg·kg-1 body weight. Blood was collected when rats are suffering from hyperlipidemia and after the 30 d treatment of methanolic extract of parijoto (M. speciosa). Rats were sacrificed after the 30 d treatment. The serum level of triglycerides was determined and the increase in body weight was measured weekly. Results showed that giving of methanolic extract of parijoto (M. speciosa) in hyperlipidemic rats reduced the triglycerides levels significantly (p < 0.01), the increase of body weight until 34 % and the adipose tissue in the peritoneum of hyperlipidemic rats.

KW - hyperlipidemia

KW - obesity

KW - parijoto

KW - triglycerides

UR - https://www.scopus.com/pages/publications/85052404048

U2 - 10.1063/1.5050142

DO - 10.1063/1.5050142

M3 - Conference contribution

AN - SCOPUS:85052404048

SN - 9780735417182

T3 - AIP Conference Proceedings

BT - Inventing Prosperous Future through Biological Research and Tropical Biodiversity Management

A2 - Rohmah, Zuliyati

A2 - Hidayati, Lisna

A2 - Arisuryanti, Tuty

A2 - Maryani, null

A2 - Aristya, Ganies Riza

PB - American Institute of Physics Inc.

T2 - 5th International Conference on Biological Science: Inventing Prosperous Future through Biological Research and Tropical Biodiversity Management, ICBS 2017

Y2 - 15 September 2017 through 16 September 2017

ER -

Sa'Adah NN , Nurhayati APD , Purwani KI. Antihyperlipidemic and anti-obesity effects of the methanolic extract of parijoto (Medinilla speciosa). In Rohmah Z, Hidayati L, Arisuryanti T, Maryani, Aristya GR, editors, Inventing Prosperous Future through Biological Research and Tropical Biodiversity Management: Proceedings of the 5th International Conference on Biological Science. American Institute of Physics Inc. 2018. 020046. (AIP Conference Proceedings). doi: 10.1063/1.5050142

Antihyperlipidemic and anti-obesity effects of the methanolic extract of parijoto (Medinilla speciosa)

Abstract

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UN SDGs

Keywords

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