Antimicrobial enzymes: An emerging strategy to fight microbes and microbial biofilms

Barbara Thallinger, Endry N. Prasetyo, Gibson S. Nyanhongo*, Georg M. Guebitz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

255 Citations (Scopus)


With the increasing prevalence of antibiotic resistance, antimicrobial enzymes aimed at the disruption of bacterial cellular machinery and biofilm formation are under intense investigation. Several enzyme-based products have already been commercialized for application in the healthcare, food and biomedical industries. Successful removal of complex biofilms requires the use of multi-enzyme formulations that contain enzymes capable of degrading microbial DNA, polysaccharides, proteins and quorum-sensing molecules. The inclusion of anti-quorum sensing enzymes prevents biofilm reformation. The development of effective complex enzyme formulations is urgently needed to deal with the problems associated with biofilm formation in manufacturing, environmental protection and healthcare settings. Nevertheless, advances in synthetic biology, enzyme engineering and whole DNA-Sequencing technologies show great potential to facilitate the development of more effective antimicrobial and anti-biofilm enzymes.

Original languageEnglish
Pages (from-to)97-109
Number of pages13
JournalBiotechnology Journal
Issue number1
Publication statusPublished - Jan 2013
Externally publishedYes


  • Anti-biofilm enzymes
  • Antimicrobial enzymes
  • Microbial biofilm


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