Antioxidant, α-glucosidase inhibitory, and cytotoxic activities of Mangifera rufocostata extract and identification of its compounds by LC-MS/MS analysis

Kamilia Mustikasari, Mardi Santoso, Mohd Fadzelly Abu Bakar, Sri Fatmawati*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Mangifera rufocostata, a member of the Mangifera genus, is a source of secondary metabolites and has been used traditionally as antidiabetic agent. Therefore, this study aims to determine the total flavonoid contens (TFC), total phenolic contents (TPC), antioxidant, α-glucosidase inhibitory, and cytotoxic activities of M. rufocostata stem bark extract. Antioxidant activity were evaluated by 2-2″-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS), 1,1-diphenyl-2-picrylhydrazyl (DPPH), and ferric reducing-antioxidant power (FRAP) tests. α-glucosidase inhibitory to prediction antidiabetic activity, and cytotoxic activity were studied against HT-29, HeLa, and MCF-7 cancer cell lines. The results showed that the methanol extract have the highest TFC, TPC, antioxidant, and α-glucosidase inhibitory activity. Furthermore, the methanol extract has strong cytotoxicity againts HT-29 cancer cells. Based on LC-MS/MS, the methanol extract contain several major compounds such as mangiferin, quinic acid, gallic acid, and 3-methoxy-4-hydroxy-phenyl glycol.

Original languageEnglish
Article number105391
JournalArabian Journal of Chemistry
Volume17
Issue number1
DOIs
Publication statusPublished - Jan 2024

Keywords

  • Antioxidant
  • Cytotoxic
  • LC-MS/MS
  • M. rufocostata
  • α-glucosidase inhibitory

Fingerprint

Dive into the research topics of 'Antioxidant, α-glucosidase inhibitory, and cytotoxic activities of Mangifera rufocostata extract and identification of its compounds by LC-MS/MS analysis'. Together they form a unique fingerprint.

Cite this