Assessment of the microbiome role in skin protection against UV irradiation via network analysis

Mohammad Hossein Heidari; Mohammadreza Razzaghi; Alireza Akbarzadeh Baghban; Mohammad Rostami-Nejad; Mostafa Rezaei-Tavirani; Mona Zamanian Azodi; Alireza Zali; Alireza Ahmadzadeh

doi:10.34172/jlms.2020.40

Assessment of the microbiome role in skin protection against UV irradiation via network analysis

Mohammad Hossein Heidari
, Mohammadreza Razzaghi
, Alireza Akbarzadeh Baghban
, Mohammad Rostami-Nejad
, Mostafa Rezaei-Tavirani
, Mona Zamanian Azodi^*
, Alireza Zali
, Alireza Ahmadzadeh

^*Corresponding author for this work

Shahid Beheshti University of Medical Sciences

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Introduction: Diverse microbiotas which have some contributions to gene expression reside in human skin. To identify the protective role of the skin microbiome against UV exposure, protein-protein interaction (PPI) network analysis is used to assessment gene expression alteration. Methods: A microarray dataset, GEO accession number GSE117359, was considered in this respect. Differential expressed genes (DEGs) in the germ-free (GF) and specific pathogen-free (SPF) groups are analyzed by GEO2R. The top significant DEGs were assigned for network analysis via Cytoscape 3.7.2 and its applications. Results: A total of 28 genes were identified as significant DEGs and the centrality analysis of the network indicated that only one of the seven hub-bottlenecks was from queried genes. The gene ontology analysis of Il6, Cxcl2, Cxcl1, TNF, Il10, Cxcl10, and Mmp9 showed that the crucial genes were highly enriched in the immune system. Conclusion: The skin microbiome plays a significant role in the protection of skin against UV irradiation and the role of TNF and IL6 is prominent in this regard.

Original language	English
Pages (from-to)	238-242
Number of pages	5
Journal	Journal of Lasers in Medical Sciences
Volume	11
Issue number	3
DOIs	https://doi.org/10.34172/jlms.2020.40
Publication status	Published - 1 Jun 2020
Externally published	Yes

Keywords

Gene expression
Microbiome
Protein-protein interaction network
UV radiation

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10.34172/jlms.2020.40

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title = "Assessment of the microbiome role in skin protection against UV irradiation via network analysis",

abstract = "Introduction: Diverse microbiotas which have some contributions to gene expression reside in human skin. To identify the protective role of the skin microbiome against UV exposure, protein-protein interaction (PPI) network analysis is used to assessment gene expression alteration. Methods: A microarray dataset, GEO accession number GSE117359, was considered in this respect. Differential expressed genes (DEGs) in the germ-free (GF) and specific pathogen-free (SPF) groups are analyzed by GEO2R. The top significant DEGs were assigned for network analysis via Cytoscape 3.7.2 and its applications. Results: A total of 28 genes were identified as significant DEGs and the centrality analysis of the network indicated that only one of the seven hub-bottlenecks was from queried genes. The gene ontology analysis of Il6, Cxcl2, Cxcl1, TNF, Il10, Cxcl10, and Mmp9 showed that the crucial genes were highly enriched in the immune system. Conclusion: The skin microbiome plays a significant role in the protection of skin against UV irradiation and the role of TNF and IL6 is prominent in this regard.",

keywords = "Gene expression, Microbiome, Protein-protein interaction network, UV radiation",

author = "Heidari, \{Mohammad Hossein\} and Mohammadreza Razzaghi and Baghban, \{Alireza Akbarzadeh\} and Mohammad Rostami-Nejad and Mostafa Rezaei-Tavirani and Azodi, \{Mona Zamanian\} and Alireza Zali and Alireza Ahmadzadeh",

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year = "2020",

month = jun,

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doi = "10.34172/jlms.2020.40",

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T1 - Assessment of the microbiome role in skin protection against UV irradiation via network analysis

AU - Heidari, Mohammad Hossein

AU - Razzaghi, Mohammadreza

AU - Baghban, Alireza Akbarzadeh

AU - Rostami-Nejad, Mohammad

AU - Rezaei-Tavirani, Mostafa

AU - Azodi, Mona Zamanian

AU - Zali, Alireza

AU - Ahmadzadeh, Alireza

PY - 2020/6/1

Y1 - 2020/6/1

N2 - Introduction: Diverse microbiotas which have some contributions to gene expression reside in human skin. To identify the protective role of the skin microbiome against UV exposure, protein-protein interaction (PPI) network analysis is used to assessment gene expression alteration. Methods: A microarray dataset, GEO accession number GSE117359, was considered in this respect. Differential expressed genes (DEGs) in the germ-free (GF) and specific pathogen-free (SPF) groups are analyzed by GEO2R. The top significant DEGs were assigned for network analysis via Cytoscape 3.7.2 and its applications. Results: A total of 28 genes were identified as significant DEGs and the centrality analysis of the network indicated that only one of the seven hub-bottlenecks was from queried genes. The gene ontology analysis of Il6, Cxcl2, Cxcl1, TNF, Il10, Cxcl10, and Mmp9 showed that the crucial genes were highly enriched in the immune system. Conclusion: The skin microbiome plays a significant role in the protection of skin against UV irradiation and the role of TNF and IL6 is prominent in this regard.

AB - Introduction: Diverse microbiotas which have some contributions to gene expression reside in human skin. To identify the protective role of the skin microbiome against UV exposure, protein-protein interaction (PPI) network analysis is used to assessment gene expression alteration. Methods: A microarray dataset, GEO accession number GSE117359, was considered in this respect. Differential expressed genes (DEGs) in the germ-free (GF) and specific pathogen-free (SPF) groups are analyzed by GEO2R. The top significant DEGs were assigned for network analysis via Cytoscape 3.7.2 and its applications. Results: A total of 28 genes were identified as significant DEGs and the centrality analysis of the network indicated that only one of the seven hub-bottlenecks was from queried genes. The gene ontology analysis of Il6, Cxcl2, Cxcl1, TNF, Il10, Cxcl10, and Mmp9 showed that the crucial genes were highly enriched in the immune system. Conclusion: The skin microbiome plays a significant role in the protection of skin against UV irradiation and the role of TNF and IL6 is prominent in this regard.

KW - Gene expression

KW - Microbiome

KW - Protein-protein interaction network

KW - UV radiation

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DO - 10.34172/jlms.2020.40

M3 - Article

AN - SCOPUS:85088241154

SN - 2008-9783

VL - 11

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EP - 242

JO - Journal of Lasers in Medical Sciences

JF - Journal of Lasers in Medical Sciences

IS - 3

ER -

Assessment of the microbiome role in skin protection against UV irradiation via network analysis

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Keywords

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