Biochemical activities of new isatin derivative against WiDr colon cancer

B. Prayitno, M. Santoso

Research output: Contribution to journalConference articlepeer-review


One of the harmful cancer and the major contributors to deaths is colon cancer. Isatin and its derivatives are widely studied for pharmacological activity. Some isatin compounds with pyrrole, halogen, and hydroxyl substituents have anticancer bioactivity. In the present work, a new isatin derivative, 5-fluoro-3-hydroxy-3-(1H-pyrrole-2-yl)indolin-2-one, has been successfully synthesized with a yield of 66%. The aim of this study is to test the compound cytotoxicity against WiDr colon cancer cells. The cell viability was determined through MTT assay using the ELISA reader instruments. Bioactivity test revealed that 5-fluoro-3-hydroxy-3-(1H-pyrrole-2-yl) indolin-2-one was cytotoxic against WiDr colon cancer cells IC50 for 410 μg/ml.

Original languageEnglish
Article number012017
JournalJournal of Physics: Conference Series
Issue number1
Publication statusPublished - 9 Jan 2020
Event1st International Conference on Mathematics, Science and Computer Education, IC-MSCEdu 2019 - Banjarmasin, South Kalimantan, Indonesia
Duration: 7 Aug 20198 Aug 2019


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