Biochemical activities of new isatin derivative against WiDr colon cancer

B. Prayitno; M. Santoso

doi:10.1088/1742-6596/1422/1/012017

Biochemical activities of new isatin derivative against WiDr colon cancer

B. Prayitno, M. Santoso

STKIP PGRI Banjarmasin

Research output: Contribution to journal › Conference article › peer-review

Abstract

One of the harmful cancer and the major contributors to deaths is colon cancer. Isatin and its derivatives are widely studied for pharmacological activity. Some isatin compounds with pyrrole, halogen, and hydroxyl substituents have anticancer bioactivity. In the present work, a new isatin derivative, 5-fluoro-3-hydroxy-3-(1H-pyrrole-2-yl)indolin-2-one, has been successfully synthesized with a yield of 66%. The aim of this study is to test the compound cytotoxicity against WiDr colon cancer cells. The cell viability was determined through MTT assay using the ELISA reader instruments. Bioactivity test revealed that 5-fluoro-3-hydroxy-3-(1H-pyrrole-2-yl) indolin-2-one was cytotoxic against WiDr colon cancer cells IC₅₀ for 410 μg/ml.

Original language	English
Article number	012017
Journal	Journal of Physics: Conference Series
Volume	1422
Issue number	1
DOIs	https://doi.org/10.1088/1742-6596/1422/1/012017
Publication status	Published - 9 Jan 2020
Event	1st International Conference on Mathematics, Science and Computer Education, IC-MSCEdu 2019 - Banjarmasin, South Kalimantan, Indonesia Duration: 7 Aug 2019 → 8 Aug 2019

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10.1088/1742-6596/1422/1/012017

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title = "Biochemical activities of new isatin derivative against WiDr colon cancer",

abstract = "One of the harmful cancer and the major contributors to deaths is colon cancer. Isatin and its derivatives are widely studied for pharmacological activity. Some isatin compounds with pyrrole, halogen, and hydroxyl substituents have anticancer bioactivity. In the present work, a new isatin derivative, 5-fluoro-3-hydroxy-3-(1H-pyrrole-2-yl)indolin-2-one, has been successfully synthesized with a yield of 66%. The aim of this study is to test the compound cytotoxicity against WiDr colon cancer cells. The cell viability was determined through MTT assay using the ELISA reader instruments. Bioactivity test revealed that 5-fluoro-3-hydroxy-3-(1H-pyrrole-2-yl) indolin-2-one was cytotoxic against WiDr colon cancer cells IC50 for 410 μg/ml.",

author = "B. Prayitno and M. Santoso",

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T1 - Biochemical activities of new isatin derivative against WiDr colon cancer

AU - Prayitno, B.

AU - Santoso, M.

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N2 - One of the harmful cancer and the major contributors to deaths is colon cancer. Isatin and its derivatives are widely studied for pharmacological activity. Some isatin compounds with pyrrole, halogen, and hydroxyl substituents have anticancer bioactivity. In the present work, a new isatin derivative, 5-fluoro-3-hydroxy-3-(1H-pyrrole-2-yl)indolin-2-one, has been successfully synthesized with a yield of 66%. The aim of this study is to test the compound cytotoxicity against WiDr colon cancer cells. The cell viability was determined through MTT assay using the ELISA reader instruments. Bioactivity test revealed that 5-fluoro-3-hydroxy-3-(1H-pyrrole-2-yl) indolin-2-one was cytotoxic against WiDr colon cancer cells IC50 for 410 μg/ml.

AB - One of the harmful cancer and the major contributors to deaths is colon cancer. Isatin and its derivatives are widely studied for pharmacological activity. Some isatin compounds with pyrrole, halogen, and hydroxyl substituents have anticancer bioactivity. In the present work, a new isatin derivative, 5-fluoro-3-hydroxy-3-(1H-pyrrole-2-yl)indolin-2-one, has been successfully synthesized with a yield of 66%. The aim of this study is to test the compound cytotoxicity against WiDr colon cancer cells. The cell viability was determined through MTT assay using the ELISA reader instruments. Bioactivity test revealed that 5-fluoro-3-hydroxy-3-(1H-pyrrole-2-yl) indolin-2-one was cytotoxic against WiDr colon cancer cells IC50 for 410 μg/ml.

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U2 - 10.1088/1742-6596/1422/1/012017

DO - 10.1088/1742-6596/1422/1/012017

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JO - Journal of Physics: Conference Series

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T2 - 1st International Conference on Mathematics, Science and Computer Education, IC-MSCEdu 2019

Y2 - 7 August 2019 through 8 August 2019

ER -

Biochemical activities of new isatin derivative against WiDr colon cancer

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