TY - GEN
T1 - Blood plasma separation in ZnO nanoflowers-supported paper based microfluidic for glucose sensing
AU - Muhimmah, Luthviyah Choirotul
AU - Roekmono,
AU - Hadi, Harsono
AU - Yuwono, Rio Akbar
AU - Wahyuono, Ruri Agung
N1 - Publisher Copyright:
© 2018 Author(s).
PY - 2018/4/3
Y1 - 2018/4/3
N2 - Blood plasma separation is essential to analyze and quantify the bio-substances in the human blood and hence, allows for diagnosing various diseases. This paper presents the two layer paper-based microfluidic analytical devices coated with ZnO nanoflowers (ZnO NF-μPAD) for a rapid blood plasma separation and glucose sensing. Plasma separation in ZnO NF-μPAD was evaluated experimentally and numerically using computational fluid dynamics package for a flow over porous networks. Glucose detection was carried out using Fourier-transform infrared (FTIR) measurements. The glucose concentrations in the red blood samples investigated here vary in the range of 150 - 310 mg·dl-1. The plasma separation process on ZnO NF-μPAD requires 240 ± 93 s. The spectroscopic data reveals that the IR absorptions and Raman signals at the typical vibrational frequencies of glucose are increasing at higher glucose concentration. After subtraction from absorption background arising from ZnO NF and the paper, linearly increasing IR absorption (913 and 1349 cm-1) and Raman signals (1346 and 1461 cm-1) are observable with a relatively good sensitivity.
AB - Blood plasma separation is essential to analyze and quantify the bio-substances in the human blood and hence, allows for diagnosing various diseases. This paper presents the two layer paper-based microfluidic analytical devices coated with ZnO nanoflowers (ZnO NF-μPAD) for a rapid blood plasma separation and glucose sensing. Plasma separation in ZnO NF-μPAD was evaluated experimentally and numerically using computational fluid dynamics package for a flow over porous networks. Glucose detection was carried out using Fourier-transform infrared (FTIR) measurements. The glucose concentrations in the red blood samples investigated here vary in the range of 150 - 310 mg·dl-1. The plasma separation process on ZnO NF-μPAD requires 240 ± 93 s. The spectroscopic data reveals that the IR absorptions and Raman signals at the typical vibrational frequencies of glucose are increasing at higher glucose concentration. After subtraction from absorption background arising from ZnO NF and the paper, linearly increasing IR absorption (913 and 1349 cm-1) and Raman signals (1346 and 1461 cm-1) are observable with a relatively good sensitivity.
UR - http://www.scopus.com/inward/record.url?scp=85045657399&partnerID=8YFLogxK
U2 - 10.1063/1.5030228
DO - 10.1063/1.5030228
M3 - Conference contribution
AN - SCOPUS:85045657399
T3 - AIP Conference Proceedings
BT - Proceedings of the 3rd International Conference on Materials and Metallurgical Engineering and Technology, ICOMMET 2017
A2 - Hidayat, Mas Irfan P.
PB - American Institute of Physics Inc.
T2 - 3rd International Conference on Materials and Metallurgical Engineering and Technology: Advancing Innovation in Materials Science, Technology and Applications for Sustainable Future, ICOMMET 2017
Y2 - 30 October 2017 through 31 October 2017
ER -