Blood plasma separation in ZnO nanoflowers-supported paper based microfluidic for glucose sensing

Luthviyah Choirotul Muhimmah; Roekmono; Harsono Hadi; Rio Akbar Yuwono; Ruri Agung Wahyuono

doi:10.1063/1.5030228

Blood plasma separation in ZnO nanoflowers-supported paper based microfluidic for glucose sensing

Luthviyah Choirotul Muhimmah^*
, Roekmono
, Harsono Hadi
, Rio Akbar Yuwono
, Ruri Agung Wahyuono

^*Corresponding author for this work

Institut Teknologi Sepuluh Nopember

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

3 Citations (Scopus)

Abstract

Blood plasma separation is essential to analyze and quantify the bio-substances in the human blood and hence, allows for diagnosing various diseases. This paper presents the two layer paper-based microfluidic analytical devices coated with ZnO nanoflowers (ZnO NF-μPAD) for a rapid blood plasma separation and glucose sensing. Plasma separation in ZnO NF-μPAD was evaluated experimentally and numerically using computational fluid dynamics package for a flow over porous networks. Glucose detection was carried out using Fourier-transform infrared (FTIR) measurements. The glucose concentrations in the red blood samples investigated here vary in the range of 150 - 310 mg·dl-1. The plasma separation process on ZnO NF-μPAD requires 240 ± 93 s. The spectroscopic data reveals that the IR absorptions and Raman signals at the typical vibrational frequencies of glucose are increasing at higher glucose concentration. After subtraction from absorption background arising from ZnO NF and the paper, linearly increasing IR absorption (913 and 1349 cm^-1) and Raman signals (1346 and 1461 cm^-1) are observable with a relatively good sensitivity.

Original language	English
Title of host publication	Proceedings of the 3rd International Conference on Materials and Metallurgical Engineering and Technology, ICOMMET 2017
Subtitle of host publication	Advancing Innovation in Materials Science, Technology and Applications for Sustainable Future
Editors	Mas Irfan P. Hidayat
Publisher	American Institute of Physics Inc.
ISBN (Electronic)	9780735416406
DOIs	https://doi.org/10.1063/1.5030228
Publication status	Published - 3 Apr 2018
Event	3rd International Conference on Materials and Metallurgical Engineering and Technology: Advancing Innovation in Materials Science, Technology and Applications for Sustainable Future, ICOMMET 2017 - Surabaya, Indonesia Duration: 30 Oct 2017 → 31 Oct 2017

Publication series

Name	AIP Conference Proceedings
Volume	1945
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Conference

Conference	3rd International Conference on Materials and Metallurgical Engineering and Technology: Advancing Innovation in Materials Science, Technology and Applications for Sustainable Future, ICOMMET 2017
Country/Territory	Indonesia
City	Surabaya
Period	30/10/17 → 31/10/17

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1063/1.5030228

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Muhimmah, L. C., Roekmono, Hadi, H., Yuwono, R. A., & Wahyuono, R. A. (2018). Blood plasma separation in ZnO nanoflowers-supported paper based microfluidic for glucose sensing. In M. I. P. Hidayat (Ed.), Proceedings of the 3rd International Conference on Materials and Metallurgical Engineering and Technology, ICOMMET 2017: Advancing Innovation in Materials Science, Technology and Applications for Sustainable Future Article 020006 (AIP Conference Proceedings; Vol. 1945). American Institute of Physics Inc.. https://doi.org/10.1063/1.5030228

Muhimmah, Luthviyah Choirotul ; Roekmono ; Hadi, Harsono et al. / Blood plasma separation in ZnO nanoflowers-supported paper based microfluidic for glucose sensing. Proceedings of the 3rd International Conference on Materials and Metallurgical Engineering and Technology, ICOMMET 2017: Advancing Innovation in Materials Science, Technology and Applications for Sustainable Future. editor / Mas Irfan P. Hidayat. American Institute of Physics Inc., 2018. (AIP Conference Proceedings).

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title = "Blood plasma separation in ZnO nanoflowers-supported paper based microfluidic for glucose sensing",

abstract = "Blood plasma separation is essential to analyze and quantify the bio-substances in the human blood and hence, allows for diagnosing various diseases. This paper presents the two layer paper-based microfluidic analytical devices coated with ZnO nanoflowers (ZnO NF-μPAD) for a rapid blood plasma separation and glucose sensing. Plasma separation in ZnO NF-μPAD was evaluated experimentally and numerically using computational fluid dynamics package for a flow over porous networks. Glucose detection was carried out using Fourier-transform infrared (FTIR) measurements. The glucose concentrations in the red blood samples investigated here vary in the range of 150 - 310 mg·dl-1. The plasma separation process on ZnO NF-μPAD requires 240 ± 93 s. The spectroscopic data reveals that the IR absorptions and Raman signals at the typical vibrational frequencies of glucose are increasing at higher glucose concentration. After subtraction from absorption background arising from ZnO NF and the paper, linearly increasing IR absorption (913 and 1349 cm-1) and Raman signals (1346 and 1461 cm-1) are observable with a relatively good sensitivity.",

author = "Muhimmah, \{Luthviyah Choirotul\} and Roekmono and Harsono Hadi and Yuwono, \{Rio Akbar\} and Wahyuono, \{Ruri Agung\}",

note = "Publisher Copyright: {\textcopyright} 2018 Author(s).; 3rd International Conference on Materials and Metallurgical Engineering and Technology: Advancing Innovation in Materials Science, Technology and Applications for Sustainable Future, ICOMMET 2017 ; Conference date: 30-10-2017 Through 31-10-2017",

year = "2018",

month = apr,

day = "3",

doi = "10.1063/1.5030228",

language = "English",

series = "AIP Conference Proceedings",

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Muhimmah, LC, Roekmono, Hadi, H, Yuwono, RA & Wahyuono, RA 2018, Blood plasma separation in ZnO nanoflowers-supported paper based microfluidic for glucose sensing. in MIP Hidayat (ed.), Proceedings of the 3rd International Conference on Materials and Metallurgical Engineering and Technology, ICOMMET 2017: Advancing Innovation in Materials Science, Technology and Applications for Sustainable Future., 020006, AIP Conference Proceedings, vol. 1945, American Institute of Physics Inc., 3rd International Conference on Materials and Metallurgical Engineering and Technology: Advancing Innovation in Materials Science, Technology and Applications for Sustainable Future, ICOMMET 2017, Surabaya, Indonesia, 30/10/17. https://doi.org/10.1063/1.5030228

Blood plasma separation in ZnO nanoflowers-supported paper based microfluidic for glucose sensing. / Muhimmah, Luthviyah Choirotul; Roekmono; Hadi, Harsono et al.
Proceedings of the 3rd International Conference on Materials and Metallurgical Engineering and Technology, ICOMMET 2017: Advancing Innovation in Materials Science, Technology and Applications for Sustainable Future. ed. / Mas Irfan P. Hidayat. American Institute of Physics Inc., 2018. 020006 (AIP Conference Proceedings; Vol. 1945).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Blood plasma separation in ZnO nanoflowers-supported paper based microfluidic for glucose sensing

AU - Muhimmah, Luthviyah Choirotul

AU - Roekmono,

AU - Hadi, Harsono

AU - Yuwono, Rio Akbar

AU - Wahyuono, Ruri Agung

PY - 2018/4/3

Y1 - 2018/4/3

N2 - Blood plasma separation is essential to analyze and quantify the bio-substances in the human blood and hence, allows for diagnosing various diseases. This paper presents the two layer paper-based microfluidic analytical devices coated with ZnO nanoflowers (ZnO NF-μPAD) for a rapid blood plasma separation and glucose sensing. Plasma separation in ZnO NF-μPAD was evaluated experimentally and numerically using computational fluid dynamics package for a flow over porous networks. Glucose detection was carried out using Fourier-transform infrared (FTIR) measurements. The glucose concentrations in the red blood samples investigated here vary in the range of 150 - 310 mg·dl-1. The plasma separation process on ZnO NF-μPAD requires 240 ± 93 s. The spectroscopic data reveals that the IR absorptions and Raman signals at the typical vibrational frequencies of glucose are increasing at higher glucose concentration. After subtraction from absorption background arising from ZnO NF and the paper, linearly increasing IR absorption (913 and 1349 cm-1) and Raman signals (1346 and 1461 cm-1) are observable with a relatively good sensitivity.

AB - Blood plasma separation is essential to analyze and quantify the bio-substances in the human blood and hence, allows for diagnosing various diseases. This paper presents the two layer paper-based microfluidic analytical devices coated with ZnO nanoflowers (ZnO NF-μPAD) for a rapid blood plasma separation and glucose sensing. Plasma separation in ZnO NF-μPAD was evaluated experimentally and numerically using computational fluid dynamics package for a flow over porous networks. Glucose detection was carried out using Fourier-transform infrared (FTIR) measurements. The glucose concentrations in the red blood samples investigated here vary in the range of 150 - 310 mg·dl-1. The plasma separation process on ZnO NF-μPAD requires 240 ± 93 s. The spectroscopic data reveals that the IR absorptions and Raman signals at the typical vibrational frequencies of glucose are increasing at higher glucose concentration. After subtraction from absorption background arising from ZnO NF and the paper, linearly increasing IR absorption (913 and 1349 cm-1) and Raman signals (1346 and 1461 cm-1) are observable with a relatively good sensitivity.

UR - https://www.scopus.com/pages/publications/85045657399

U2 - 10.1063/1.5030228

DO - 10.1063/1.5030228

M3 - Conference contribution

AN - SCOPUS:85045657399

T3 - AIP Conference Proceedings

BT - Proceedings of the 3rd International Conference on Materials and Metallurgical Engineering and Technology, ICOMMET 2017

A2 - Hidayat, Mas Irfan P.

PB - American Institute of Physics Inc.

T2 - 3rd International Conference on Materials and Metallurgical Engineering and Technology: Advancing Innovation in Materials Science, Technology and Applications for Sustainable Future, ICOMMET 2017

Y2 - 30 October 2017 through 31 October 2017

ER -

Muhimmah LC, Roekmono, Hadi H, Yuwono RA, Wahyuono RA. Blood plasma separation in ZnO nanoflowers-supported paper based microfluidic for glucose sensing. In Hidayat MIP, editor, Proceedings of the 3rd International Conference on Materials and Metallurgical Engineering and Technology, ICOMMET 2017: Advancing Innovation in Materials Science, Technology and Applications for Sustainable Future. American Institute of Physics Inc. 2018. 020006. (AIP Conference Proceedings). doi: 10.1063/1.5030228

Blood plasma separation in ZnO nanoflowers-supported paper based microfluidic for glucose sensing

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