This research is the initial phase of an extensive study that will verify the relationship between interiors and increasing positive emotions of users in health facilities. The stages reported in this journal are the stages of clarifying virtual reality tools, intending to know the safety of virtual reality tools for interior visualization trials in children. The next stage reported was three stages of visualization of the chemotherapy room. First, it is with the original condition, then changing the color of the walls to a bright and striking color, and finally with calm color. This analysis also wants to prove the readiness of children to determine design preferences. This experiment is conducted on children over nine years and under nine to determine the preferences of colored children. Based on the experimental results, children aged nine years and over are known to be more able to decide on a clear preference for color than children aged under nine years. The test method uses virtual reality to experiment with visual stimulation in the form of color, accompanied by in-depth interviews.