There has been many low-swing on-chip interconnect signaling techniques introduced to tackle the problem of inverse-scaling effect of on-chip wires. This paper proposes a comparison framework using SPICE-based simulations on the 90nm technology node, which is needed to assess the effectiveness of a certain interconnect technique over the others with a high degree of objectiveness and accuracy. Two low-swing techniques are included in the comparison, i.e. conventional level converter (CLC) and current-mode signaling (CM). These techniques were chosen to represent different driver and receiver topologies, where CLC uses lower driver supply voltage, while CM has a low impedance termination at receiver end. In addition, an optimized full-swing repeater-based technique is included as a baseline for comparison. The main contribution of this paper is the identification of circuit and wire design parameters that affects performances the most, leading to a design guideline with reduced set of design variables for delay or energy optimization of each technique. A simplified repeater performance estimation technique considering ramp input signals is also proposed. Furthermore, trade-off between energy and delay using the optimization processes has been explored, resulting in a more objective comparison of different interconnect techniques in the power-delay space. Results show that optimized CLC (reduced voltage supply) repeaters can perform better in both terms of delay and power in its design performance range.