Composite Based Chitosan/Zinc-Doped HA as a Candidate Material for Bone Substitute Applications

S. T. Wicaksono; A. Rasyida; A. Purnomo; N. N. Pradita; H. Ardhyananta; M. I.P. Hidayat

doi:10.1088/1757-899X/202/1/012080

Composite Based Chitosan/Zinc-Doped HA as a Candidate Material for Bone Substitute Applications

S. T. Wicaksono, A. Rasyida^*, A. Purnomo, N. N. Pradita, H. Ardhyananta, M. I.P. Hidayat

^*Corresponding author for this work

Institut Teknologi Sepuluh Nopember

Research output: Contribution to journal › Conference article › peer-review

4 Citations (Scopus)

Abstract

The composite based Zinc-doped in Chitosan/Hydroxyapatite was successfully prepared by wet mixing method through the addition of 10, 15, and 20wt% of chitosan. The addition of Chitosan increased the compressive strength and the modulus elasticity. However, it decreased the density and the surface hardness of HA-Zn. Mechanical characterization revealed that these composites are suitable as a candidate of a cancellous bone substitute. Composite with 10% chitosan has compressive strength and modulus elasticity of 57.03 MPa and 0.15 GPa, respectively. Hence, it has the physical and mechanical properties that meet the standards as a cancellous bone substitute material. Also, in vitro biocompatibility test against BHK-21 cells exhibited non-toxic materials.

Original language	English
Article number	012080
Journal	IOP Conference Series: Materials Science and Engineering
Volume	202
Issue number	1
DOIs	https://doi.org/10.1088/1757-899X/202/1/012080
Publication status	Published - 31 May 2017
Event	4th International Conference on Advanced Materials Science and Technology 2016, ICAMST 2016 - Malang, Indonesia Duration: 27 Sept 2016 → 28 Sept 2016

Keywords

HA
bone
chitosan
composite
zinc

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10.1088/1757-899X/202/1/012080

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title = "Composite Based Chitosan/Zinc-Doped HA as a Candidate Material for Bone Substitute Applications",

abstract = "The composite based Zinc-doped in Chitosan/Hydroxyapatite was successfully prepared by wet mixing method through the addition of 10, 15, and 20wt% of chitosan. The addition of Chitosan increased the compressive strength and the modulus elasticity. However, it decreased the density and the surface hardness of HA-Zn. Mechanical characterization revealed that these composites are suitable as a candidate of a cancellous bone substitute. Composite with 10% chitosan has compressive strength and modulus elasticity of 57.03 MPa and 0.15 GPa, respectively. Hence, it has the physical and mechanical properties that meet the standards as a cancellous bone substitute material. Also, in vitro biocompatibility test against BHK-21 cells exhibited non-toxic materials.",

keywords = "HA, bone, chitosan, composite, zinc",

author = "Wicaksono, {S. T.} and A. Rasyida and A. Purnomo and Pradita, {N. N.} and H. Ardhyananta and Hidayat, {M. I.P.}",

note = "Publisher Copyright: {\textcopyright} Published under licence by IOP Publishing Ltd.; 4th International Conference on Advanced Materials Science and Technology 2016, ICAMST 2016 ; Conference date: 27-09-2016 Through 28-09-2016",

year = "2017",

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day = "31",

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T1 - Composite Based Chitosan/Zinc-Doped HA as a Candidate Material for Bone Substitute Applications

AU - Wicaksono, S. T.

AU - Rasyida, A.

AU - Purnomo, A.

AU - Pradita, N. N.

AU - Ardhyananta, H.

AU - Hidayat, M. I.P.

N1 - Publisher Copyright: © Published under licence by IOP Publishing Ltd.

PY - 2017/5/31

Y1 - 2017/5/31

N2 - The composite based Zinc-doped in Chitosan/Hydroxyapatite was successfully prepared by wet mixing method through the addition of 10, 15, and 20wt% of chitosan. The addition of Chitosan increased the compressive strength and the modulus elasticity. However, it decreased the density and the surface hardness of HA-Zn. Mechanical characterization revealed that these composites are suitable as a candidate of a cancellous bone substitute. Composite with 10% chitosan has compressive strength and modulus elasticity of 57.03 MPa and 0.15 GPa, respectively. Hence, it has the physical and mechanical properties that meet the standards as a cancellous bone substitute material. Also, in vitro biocompatibility test against BHK-21 cells exhibited non-toxic materials.

AB - The composite based Zinc-doped in Chitosan/Hydroxyapatite was successfully prepared by wet mixing method through the addition of 10, 15, and 20wt% of chitosan. The addition of Chitosan increased the compressive strength and the modulus elasticity. However, it decreased the density and the surface hardness of HA-Zn. Mechanical characterization revealed that these composites are suitable as a candidate of a cancellous bone substitute. Composite with 10% chitosan has compressive strength and modulus elasticity of 57.03 MPa and 0.15 GPa, respectively. Hence, it has the physical and mechanical properties that meet the standards as a cancellous bone substitute material. Also, in vitro biocompatibility test against BHK-21 cells exhibited non-toxic materials.

KW - HA

KW - bone

KW - chitosan

KW - composite

KW - zinc

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U2 - 10.1088/1757-899X/202/1/012080

DO - 10.1088/1757-899X/202/1/012080

M3 - Conference article

AN - SCOPUS:85021776385

SN - 1757-8981

VL - 202

JO - IOP Conference Series: Materials Science and Engineering

JF - IOP Conference Series: Materials Science and Engineering

IS - 1

M1 - 012080

T2 - 4th International Conference on Advanced Materials Science and Technology 2016, ICAMST 2016

Y2 - 27 September 2016 through 28 September 2016

ER -

Composite Based Chitosan/Zinc-Doped HA as a Candidate Material for Bone Substitute Applications

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Keywords

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