The development of medical facilities is crucial in Indonesia’s remote island since COVID-19-19 disease collapses the hospital system. This work is intended to develop the COVID-19 vessel as a medical support system with a dynamic positioning system to give medical health care for Indonesia’s remote island. The COVID-19 vessel is named KM. LOTUS is arranged similarly with Type B medical facility standards. Conceptual design and performance calculation comprised weight calculation, medical facility arrangement, resistance and powering test, seakeeping performances are evaluated. The ship is equipped with an ambulance boat to increase mobility capabilities for smaller waters, such as narrow straits and estuaries. It is placed behind the ship, uses an autonomous system to climb up to the top of the deck. The resistance test has a value of 66.6 kN and a power of 383 HP at a ship speed of 12.22 knots. The seakeeping analysis was carried out using the strip theory method by simulating a ship speed of 12.22 knots representing Maluku sea condition. It can be found that different incoming waves will produce different oscillatory movements of heave, pitch, and roll.