Curcumin-Loaded Liposome Preparation in Ultrasound Environment under Pressurized Carbon Dioxide

Wahyudiono; Jiayang He; Xin Hu; Siti Machmudah; Keiji Yasuda; Seiichi Takami; Hideki Kanda; Motonobu Goto

doi:10.3390/foods11101469

Curcumin-Loaded Liposome Preparation in Ultrasound Environment under Pressurized Carbon Dioxide

Wahyudiono, Jiayang He, Xin Hu, Siti Machmudah, Keiji Yasuda, Seiichi Takami, Hideki Kanda^*, Motonobu Goto

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Curcumin-loaded liposomes were prepared using a supercritical carbon dioxide (SCCO₂ )– ultrasound environment system. The experiments were performed at temperatures of 40–70^◦C and pressures of 10–25 MPa in a batch system with ultrasonication for 60 min. Transmission electron microscopy (TEM) images revealed liposome products with spherical morphologies and diameters of <100 nm. Dynamic light scattering (DLS) analysis indicated that the curcumin-loaded liposome nanosuspension exhibited good stability. Changing the operating conditions influenced the amount of liposome-encapsulated curcumin; as the operating temperature or pressure increased, the diameter of the liposome products and the amount of liposome-encapsulated curcumin increased and decreased, respectively. Herein, we described an innovative and practical organic-solvent-free method for generating liposomes from phospholipids.

Original language	English
Article number	1469
Journal	Foods
Volume	11
Issue number	10
DOIs	https://doi.org/10.3390/foods11101469
Publication status	Published - 1 May 2022

Keywords

curcumin
encapsulation
liposome
phospholipid
supercritical

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10.3390/foods11101469

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title = "Curcumin-Loaded Liposome Preparation in Ultrasound Environment under Pressurized Carbon Dioxide",

abstract = "Curcumin-loaded liposomes were prepared using a supercritical carbon dioxide (SCCO2 )– ultrasound environment system. The experiments were performed at temperatures of 40–70◦C and pressures of 10–25 MPa in a batch system with ultrasonication for 60 min. Transmission electron microscopy (TEM) images revealed liposome products with spherical morphologies and diameters of <100 nm. Dynamic light scattering (DLS) analysis indicated that the curcumin-loaded liposome nanosuspension exhibited good stability. Changing the operating conditions influenced the amount of liposome-encapsulated curcumin; as the operating temperature or pressure increased, the diameter of the liposome products and the amount of liposome-encapsulated curcumin increased and decreased, respectively. Herein, we described an innovative and practical organic-solvent-free method for generating liposomes from phospholipids.",

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AU - Wahyudiono,

AU - He, Jiayang

AU - Hu, Xin

AU - Machmudah, Siti

AU - Yasuda, Keiji

AU - Takami, Seiichi

AU - Kanda, Hideki

AU - Goto, Motonobu

PY - 2022/5/1

Y1 - 2022/5/1

N2 - Curcumin-loaded liposomes were prepared using a supercritical carbon dioxide (SCCO2 )– ultrasound environment system. The experiments were performed at temperatures of 40–70◦C and pressures of 10–25 MPa in a batch system with ultrasonication for 60 min. Transmission electron microscopy (TEM) images revealed liposome products with spherical morphologies and diameters of <100 nm. Dynamic light scattering (DLS) analysis indicated that the curcumin-loaded liposome nanosuspension exhibited good stability. Changing the operating conditions influenced the amount of liposome-encapsulated curcumin; as the operating temperature or pressure increased, the diameter of the liposome products and the amount of liposome-encapsulated curcumin increased and decreased, respectively. Herein, we described an innovative and practical organic-solvent-free method for generating liposomes from phospholipids.

AB - Curcumin-loaded liposomes were prepared using a supercritical carbon dioxide (SCCO2 )– ultrasound environment system. The experiments were performed at temperatures of 40–70◦C and pressures of 10–25 MPa in a batch system with ultrasonication for 60 min. Transmission electron microscopy (TEM) images revealed liposome products with spherical morphologies and diameters of <100 nm. Dynamic light scattering (DLS) analysis indicated that the curcumin-loaded liposome nanosuspension exhibited good stability. Changing the operating conditions influenced the amount of liposome-encapsulated curcumin; as the operating temperature or pressure increased, the diameter of the liposome products and the amount of liposome-encapsulated curcumin increased and decreased, respectively. Herein, we described an innovative and practical organic-solvent-free method for generating liposomes from phospholipids.

KW - curcumin

KW - encapsulation

KW - liposome

KW - phospholipid

KW - supercritical

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Curcumin-Loaded Liposome Preparation in Ultrasound Environment under Pressurized Carbon Dioxide

Abstract

Keywords

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