Current Status and Recent Advances in Hydrophobic Deep Eutectic Solvents for Drug Extraction and Separation

Nur Nadhirah Mohamad Zain; Nor Munira Hashim; Noorfatimah Yahaya; Hikmat; Kartika A. Madurani

doi:10.1007/978-3-032-03801-2_11

Current Status and Recent Advances in Hydrophobic Deep Eutectic Solvents for Drug Extraction and Separation

Nur Nadhirah Mohamad Zain^*
, Nor Munira Hashim
, Noorfatimah Yahaya
, Hikmat
, Kartika A. Madurani

^*Corresponding author for this work

Department of Toxicology
Universiti Sains Malaysia
National Research and Innovation Agency Republic of Indonesia

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Citation (Scopus)

Abstract

The separation and extraction of pharmaceutical substances hold significant importance in both analytical and medicinal chemistry. The growing emphasis on eco-friendly and sustainable solvents has hydrophobic deep eutectic solvents (HDES) to the forefront as viable replacements for conventional solvents due to their biodegradability, minimal toxicity, and adjustable physicochemical properties. This chapter offers an in-depth review of HDES applications in drug separation and extraction from 2019 to 2024. It starts with foundational concepts of deep eutectic solvents (DES), elaborating on their classification, particularly distinguishing between hydrophilic and hydrophobic types. The synthesis strategies of HDES are outlined, highlighting prevalent hydrogen bond acceptors (HBAs) and hydrogen bond donors (HBDs) that contribute to hydrophobicity. Subsequent sections critically analyze HDES applications in pharmaceutical compound extraction, focusing on improvements that increase efficiency and specificity.

Original language	English
Title of host publication	Environmental Footprints and Eco-Design of Products and Processes
Publisher	Springer
Pages	281-308
Number of pages	28
DOIs	https://doi.org/10.1007/978-3-032-03801-2_11
Publication status	Published - 2026

Publication series

Name	Environmental Footprints and Eco-Design of Products and Processes
Volume	Part F1234
ISSN (Print)	2345-7651
ISSN (Electronic)	2345-766X

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 7 Affordable and Clean Energy

Keywords

Deep eutectic solvents
Drugs
Extraction
Hydrophilic
Hydrophobic
Separation
Sustainable

Access to Document

10.1007/978-3-032-03801-2_11

Cite this

Zain, N. N. M., Hashim, N. M., Yahaya, N., Hikmat, & Madurani, K. A. (2026). Current Status and Recent Advances in Hydrophobic Deep Eutectic Solvents for Drug Extraction and Separation. In Environmental Footprints and Eco-Design of Products and Processes (pp. 281-308). (Environmental Footprints and Eco-Design of Products and Processes; Vol. Part F1234). Springer. https://doi.org/10.1007/978-3-032-03801-2_11

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Zain, NNM, Hashim, NM, Yahaya, N, Hikmat, & Madurani, KA 2026, Current Status and Recent Advances in Hydrophobic Deep Eutectic Solvents for Drug Extraction and Separation. in Environmental Footprints and Eco-Design of Products and Processes. Environmental Footprints and Eco-Design of Products and Processes, vol. Part F1234, Springer, pp. 281-308. https://doi.org/10.1007/978-3-032-03801-2_11

Current Status and Recent Advances in Hydrophobic Deep Eutectic Solvents for Drug Extraction and Separation. / Zain, Nur Nadhirah Mohamad; Hashim, Nor Munira; Yahaya, Noorfatimah et al.
Environmental Footprints and Eco-Design of Products and Processes. Springer, 2026. p. 281-308 (Environmental Footprints and Eco-Design of Products and Processes; Vol. Part F1234).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

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AU - Hashim, Nor Munira

AU - Yahaya, Noorfatimah

AU - Hikmat,

AU - Madurani, Kartika A.

N1 - Publisher Copyright: © The Author(s), under exclusive license to Springer Nature Switzerland AG 2026.

PY - 2026

Y1 - 2026

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AB - The separation and extraction of pharmaceutical substances hold significant importance in both analytical and medicinal chemistry. The growing emphasis on eco-friendly and sustainable solvents has hydrophobic deep eutectic solvents (HDES) to the forefront as viable replacements for conventional solvents due to their biodegradability, minimal toxicity, and adjustable physicochemical properties. This chapter offers an in-depth review of HDES applications in drug separation and extraction from 2019 to 2024. It starts with foundational concepts of deep eutectic solvents (DES), elaborating on their classification, particularly distinguishing between hydrophilic and hydrophobic types. The synthesis strategies of HDES are outlined, highlighting prevalent hydrogen bond acceptors (HBAs) and hydrogen bond donors (HBDs) that contribute to hydrophobicity. Subsequent sections critically analyze HDES applications in pharmaceutical compound extraction, focusing on improvements that increase efficiency and specificity.

KW - Deep eutectic solvents

KW - Drugs

KW - Extraction

KW - Hydrophilic

KW - Hydrophobic

KW - Separation

KW - Sustainable

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Current Status and Recent Advances in Hydrophobic Deep Eutectic Solvents for Drug Extraction and Separation

Abstract

Publication series

UN SDGs

Keywords

Access to Document

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