Cu2O quantum dots redefining photodynamic therapy with one-minute pathogen inactivation under visible light

Azzah Dyah Pramata; Farhan Aryo Hutomo; Febriyansyah Saputra; Paundra Rizky Pratama; Taras Geonovive De Yenarosa; Sigit Tri Wicaksono; Agung Purniawan; Revianny Nidom; Shao Yang Hu

doi:10.1016/j.cscee.2025.101248

Cu₂O quantum dots redefining photodynamic therapy with one-minute pathogen inactivation under visible light

Azzah Dyah Pramata^*
, Farhan Aryo Hutomo
, Febriyansyah Saputra
, Paundra Rizky Pratama
, Taras Geonovive De Yenarosa
, Sutarsis
, Sigit Tri Wicaksono
, Agung Purniawan
, Revianny Nidom
, Shao Yang Hu

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

This work utilizes tailored – Cu₂O quantum dots (QDs) to demonstrate unprecedented pathogen photo-inactivation. The superior ROS production of the QDs synthesized at 180 °C with a size of 8.10 nm resulted in a 99.98 % reduction of MRSA, 99.78 % of Klebsiella pneumoniae, and 98.92 % of SARS-CoV Delta within 1 min under visible light. Cu₂O QDs efficiently reduced 99.25 % viability of 4T1 cancer cells in 15 min while maintaining more than 85 % viability in healthy HEK 293 cells, underlining its selectivity. This finding may establish Cu₂O QDs as the next-generation anti-pathogen agents for advanced photodynamic therapy (PDT), biomedical sterilization, and hospital applications.

Original language	English
Article number	101248
Journal	Case Studies in Chemical and Environmental Engineering
Volume	12
DOIs	https://doi.org/10.1016/j.cscee.2025.101248
Publication status	Published - Dec 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

CuO QDs
Pathogen
Photodynamic-therapy
Selective-cytotoxicity
Ultrafast

Access to Document

10.1016/j.cscee.2025.101248

Cite this

Pramata, A. D., Hutomo, F. A., Saputra, F., Pratama, P. R., De Yenarosa, T. G., Sutarsis , Wicaksono, S. T., Purniawan, A., Nidom, R., & Hu, S. Y. (2025). Cu₂O quantum dots redefining photodynamic therapy with one-minute pathogen inactivation under visible light. Case Studies in Chemical and Environmental Engineering, 12, Article 101248. https://doi.org/10.1016/j.cscee.2025.101248

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title = "Cu2O quantum dots redefining photodynamic therapy with one-minute pathogen inactivation under visible light",

abstract = "This work utilizes tailored – Cu2O quantum dots (QDs) to demonstrate unprecedented pathogen photo-inactivation. The superior ROS production of the QDs synthesized at 180 °C with a size of 8.10 nm resulted in a 99.98 \% reduction of MRSA, 99.78 \% of Klebsiella pneumoniae, and 98.92 \% of SARS-CoV Delta within 1 min under visible light. Cu2O QDs efficiently reduced 99.25 \% viability of 4T1 cancer cells in 15 min while maintaining more than 85 \% viability in healthy HEK 293 cells, underlining its selectivity. This finding may establish Cu2O QDs as the next-generation anti-pathogen agents for advanced photodynamic therapy (PDT), biomedical sterilization, and hospital applications.",

keywords = "CuO QDs, Pathogen, Photodynamic-therapy, Selective-cytotoxicity, Ultrafast",

author = "Pramata, \{Azzah Dyah\} and Hutomo, \{Farhan Aryo\} and Febriyansyah Saputra and Pratama, \{Paundra Rizky\} and \{De Yenarosa\}, \{Taras Geonovive\} and Sutarsis and Wicaksono, \{Sigit Tri\} and Agung Purniawan and Revianny Nidom and Hu, \{Shao Yang\}",

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year = "2025",

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language = "English",

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AU - Pramata, Azzah Dyah

AU - Hutomo, Farhan Aryo

AU - Saputra, Febriyansyah

AU - Pratama, Paundra Rizky

AU - De Yenarosa, Taras Geonovive

AU - Sutarsis,

AU - Wicaksono, Sigit Tri

AU - Purniawan, Agung

AU - Nidom, Revianny

AU - Hu, Shao Yang

PY - 2025/12

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N2 - This work utilizes tailored – Cu2O quantum dots (QDs) to demonstrate unprecedented pathogen photo-inactivation. The superior ROS production of the QDs synthesized at 180 °C with a size of 8.10 nm resulted in a 99.98 % reduction of MRSA, 99.78 % of Klebsiella pneumoniae, and 98.92 % of SARS-CoV Delta within 1 min under visible light. Cu2O QDs efficiently reduced 99.25 % viability of 4T1 cancer cells in 15 min while maintaining more than 85 % viability in healthy HEK 293 cells, underlining its selectivity. This finding may establish Cu2O QDs as the next-generation anti-pathogen agents for advanced photodynamic therapy (PDT), biomedical sterilization, and hospital applications.

AB - This work utilizes tailored – Cu2O quantum dots (QDs) to demonstrate unprecedented pathogen photo-inactivation. The superior ROS production of the QDs synthesized at 180 °C with a size of 8.10 nm resulted in a 99.98 % reduction of MRSA, 99.78 % of Klebsiella pneumoniae, and 98.92 % of SARS-CoV Delta within 1 min under visible light. Cu2O QDs efficiently reduced 99.25 % viability of 4T1 cancer cells in 15 min while maintaining more than 85 % viability in healthy HEK 293 cells, underlining its selectivity. This finding may establish Cu2O QDs as the next-generation anti-pathogen agents for advanced photodynamic therapy (PDT), biomedical sterilization, and hospital applications.

KW - CuO QDs

KW - Pathogen

KW - Photodynamic-therapy

KW - Selective-cytotoxicity

KW - Ultrafast

UR - https://www.scopus.com/pages/publications/105007440605

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