Kidney disease is divided into three categories, namely Chronic Kidney Disease (CKD), Acute Kidney Injury (CGK), and End Stage Kidney Disease (PGTA). Data analysis shows that from 2016 to 2017, CKD patients increased from 13.8% to 14.5%. For the treatment of CKD, a hemodialysis process is required, which the process requires dialysate fluid. Dialysate fluid is a liquid with a chemical composition similar to normal body fluids, which essential as a cleanser of dirty substances in the blood. The purpose of this study is to realize a prototype for the integration of control systems for the creation and preparation of dialysate fluid on a hemodialysis machine so that dialysate fluid can be made and used. In this study, instrumentation is produced to create and condition dialysate fluid on a hemodialysis machine. The mixing result with appropriate temperature parameters of pm 37C, the conductivity of pm 12mS/cm, and pH of pm 7 was achieved.