TY - JOUR
T1 - Effect of chitosan addition to characteristic and antimicrobial activity of zinc doped hydroxyapatite
AU - Rasyida, A.
AU - Wicaksono, S. T.
AU - Pradita, N. N.
AU - Ardhyananta, H.
AU - Purnomo, A.
N1 - Publisher Copyright:
© Published under licence by IOP Publishing Ltd.
PY - 2017/8/5
Y1 - 2017/8/5
N2 - Hydroxyapatite (HAp) doping with zinc was prepared using sol gel method; different chitosan content were further added to prepare the composite, namely 10, 15 and 20% wt. The samples were characterized using FTIR, XRD, SEM-EDX, and AAS. In vitro antimicrobial activities of the composite were evaluated against gram positive and negative bacteria. FTIR results revealed that there were no important changes in the structure of composite, while 10% wt of chitosan in composite shows the highest inhibition zone against Escherichia coli after 24 h incubation. In addition, after 7 days of immersion in simulated body fluid, there were apatite formations in the surface of the composite. These might indicate that this composite could be used as a material candidate for bone substitute applications.
AB - Hydroxyapatite (HAp) doping with zinc was prepared using sol gel method; different chitosan content were further added to prepare the composite, namely 10, 15 and 20% wt. The samples were characterized using FTIR, XRD, SEM-EDX, and AAS. In vitro antimicrobial activities of the composite were evaluated against gram positive and negative bacteria. FTIR results revealed that there were no important changes in the structure of composite, while 10% wt of chitosan in composite shows the highest inhibition zone against Escherichia coli after 24 h incubation. In addition, after 7 days of immersion in simulated body fluid, there were apatite formations in the surface of the composite. These might indicate that this composite could be used as a material candidate for bone substitute applications.
UR - http://www.scopus.com/inward/record.url?scp=85028006900&partnerID=8YFLogxK
U2 - 10.1088/1757-899X/223/1/012063
DO - 10.1088/1757-899X/223/1/012063
M3 - Conference article
AN - SCOPUS:85028006900
SN - 1757-8981
VL - 223
JO - IOP Conference Series: Materials Science and Engineering
JF - IOP Conference Series: Materials Science and Engineering
IS - 1
M1 - 012063
T2 - International Conference and Exhibition on Innovation in Polymer Science and Technology 2016, IPST 2016
Y2 - 7 November 2016 through 10 November 2016
ER -