Effect of chitosan addition to characteristic and antimicrobial activity of zinc doped hydroxyapatite

A. Rasyida; S. T. Wicaksono; N. N. Pradita; H. Ardhyananta; A. Purnomo

doi:10.1088/1757-899X/223/1/012063

Effect of chitosan addition to characteristic and antimicrobial activity of zinc doped hydroxyapatite

Department of Materials and Metallurgical Engineering
Institut Teknologi Sepuluh Nopember

Research output: Contribution to journal › Conference article › peer-review

2 Citations (Scopus)

Abstract

Hydroxyapatite (HAp) doping with zinc was prepared using sol gel method; different chitosan content were further added to prepare the composite, namely 10, 15 and 20% wt. The samples were characterized using FTIR, XRD, SEM-EDX, and AAS. In vitro antimicrobial activities of the composite were evaluated against gram positive and negative bacteria. FTIR results revealed that there were no important changes in the structure of composite, while 10% wt of chitosan in composite shows the highest inhibition zone against Escherichia coli after 24 h incubation. In addition, after 7 days of immersion in simulated body fluid, there were apatite formations in the surface of the composite. These might indicate that this composite could be used as a material candidate for bone substitute applications.

Original language	English
Article number	012063
Journal	IOP Conference Series: Materials Science and Engineering
Volume	223
Issue number	1
DOIs	https://doi.org/10.1088/1757-899X/223/1/012063
Publication status	Published - 5 Aug 2017
Event	International Conference and Exhibition on Innovation in Polymer Science and Technology 2016, IPST 2016 - Medan, North Sumatera, Indonesia Duration: 7 Nov 2016 → 10 Nov 2016

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title = "Effect of chitosan addition to characteristic and antimicrobial activity of zinc doped hydroxyapatite",

abstract = "Hydroxyapatite (HAp) doping with zinc was prepared using sol gel method; different chitosan content were further added to prepare the composite, namely 10, 15 and 20\% wt. The samples were characterized using FTIR, XRD, SEM-EDX, and AAS. In vitro antimicrobial activities of the composite were evaluated against gram positive and negative bacteria. FTIR results revealed that there were no important changes in the structure of composite, while 10\% wt of chitosan in composite shows the highest inhibition zone against Escherichia coli after 24 h incubation. In addition, after 7 days of immersion in simulated body fluid, there were apatite formations in the surface of the composite. These might indicate that this composite could be used as a material candidate for bone substitute applications.",

author = "A. Rasyida and Wicaksono, \{S. T.\} and Pradita, \{N. N.\} and H. Ardhyananta and A. Purnomo",

note = "Publisher Copyright: {\textcopyright} Published under licence by IOP Publishing Ltd.; International Conference and Exhibition on Innovation in Polymer Science and Technology 2016, IPST 2016 ; Conference date: 07-11-2016 Through 10-11-2016",

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T1 - Effect of chitosan addition to characteristic and antimicrobial activity of zinc doped hydroxyapatite

AU - Rasyida, A.

AU - Wicaksono, S. T.

AU - Pradita, N. N.

AU - Ardhyananta, H.

AU - Purnomo, A.

N1 - Publisher Copyright: © Published under licence by IOP Publishing Ltd.

PY - 2017/8/5

Y1 - 2017/8/5

N2 - Hydroxyapatite (HAp) doping with zinc was prepared using sol gel method; different chitosan content were further added to prepare the composite, namely 10, 15 and 20% wt. The samples were characterized using FTIR, XRD, SEM-EDX, and AAS. In vitro antimicrobial activities of the composite were evaluated against gram positive and negative bacteria. FTIR results revealed that there were no important changes in the structure of composite, while 10% wt of chitosan in composite shows the highest inhibition zone against Escherichia coli after 24 h incubation. In addition, after 7 days of immersion in simulated body fluid, there were apatite formations in the surface of the composite. These might indicate that this composite could be used as a material candidate for bone substitute applications.

AB - Hydroxyapatite (HAp) doping with zinc was prepared using sol gel method; different chitosan content were further added to prepare the composite, namely 10, 15 and 20% wt. The samples were characterized using FTIR, XRD, SEM-EDX, and AAS. In vitro antimicrobial activities of the composite were evaluated against gram positive and negative bacteria. FTIR results revealed that there were no important changes in the structure of composite, while 10% wt of chitosan in composite shows the highest inhibition zone against Escherichia coli after 24 h incubation. In addition, after 7 days of immersion in simulated body fluid, there were apatite formations in the surface of the composite. These might indicate that this composite could be used as a material candidate for bone substitute applications.

UR - https://www.scopus.com/pages/publications/85028006900

U2 - 10.1088/1757-899X/223/1/012063

DO - 10.1088/1757-899X/223/1/012063

M3 - Conference article

AN - SCOPUS:85028006900

SN - 1757-8981

VL - 223

JO - IOP Conference Series: Materials Science and Engineering

JF - IOP Conference Series: Materials Science and Engineering

IS - 1

M1 - 012063

T2 - International Conference and Exhibition on Innovation in Polymer Science and Technology 2016, IPST 2016

Y2 - 7 November 2016 through 10 November 2016

ER -

Effect of chitosan addition to characteristic and antimicrobial activity of zinc doped hydroxyapatite

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