TY - JOUR
T1 - Effect of Solvent on Nanoparticle Production of β-Carotene by a Supercritical Antisolvent Process
AU - Nerome, Hazuki
AU - Machmudah, Siti
AU - Wahyudiono,
AU - Fukuzato, Ryuichi
AU - Higashiura, Takuma
AU - Kanda, Hideki
AU - Goto, Motonobu
N1 - Publisher Copyright:
Copyright © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Production of micro- to nano-sized particles of β-carotene was investigated by means of solution-enhanced dispersion by supercritical fluids (SEDS). β-Carotene was dissolved in dichloromethane (DCM), N,N-dimethylformamide (DMF), n-hexane, or ethyl acetate, and supercritical CO2 served as an antisolvent. The effects of the organic solvents, operating pressure, and temperature were examined. The morphologies of the particles produced by the SEDS were observed by field emission-scanning electron microscopy and particle sizes were determined by image analysis. Irregularly shaped microparticles were produced in the system with DCM and DMF solution. Plate-like microparticles were generated by using n-hexane solution and irregular nanoparticles by ethyl acetate solution. The optimum operating conditions were found to be ethyl acetate as solvent in a defined pressure and temperature range.
AB - Production of micro- to nano-sized particles of β-carotene was investigated by means of solution-enhanced dispersion by supercritical fluids (SEDS). β-Carotene was dissolved in dichloromethane (DCM), N,N-dimethylformamide (DMF), n-hexane, or ethyl acetate, and supercritical CO2 served as an antisolvent. The effects of the organic solvents, operating pressure, and temperature were examined. The morphologies of the particles produced by the SEDS were observed by field emission-scanning electron microscopy and particle sizes were determined by image analysis. Irregularly shaped microparticles were produced in the system with DCM and DMF solution. Plate-like microparticles were generated by using n-hexane solution and irregular nanoparticles by ethyl acetate solution. The optimum operating conditions were found to be ethyl acetate as solvent in a defined pressure and temperature range.
KW - Nanoparticle formation
KW - Supercritical CO
KW - Supercritical antisolvent
KW - β-Carotene
UR - http://www.scopus.com/inward/record.url?scp=84988529996&partnerID=8YFLogxK
U2 - 10.1002/ceat.201500519
DO - 10.1002/ceat.201500519
M3 - Article
AN - SCOPUS:84988529996
SN - 0930-7516
VL - 39
SP - 1771
EP - 1777
JO - Chemical Engineering and Technology
JF - Chemical Engineering and Technology
IS - 10
ER -