Effect of Solvent on Nanoparticle Production of β-Carotene by a Supercritical Antisolvent Process

Hazuki Nerome; Siti Machmudah; Ryuichi Fukuzato; Takuma Higashiura; Hideki Kanda; Motonobu Goto

doi:10.1002/ceat.201500519

Effect of Solvent on Nanoparticle Production of β-Carotene by a Supercritical Antisolvent Process

Hazuki Nerome
, Siti Machmudah
, Wahyudiono
, Ryuichi Fukuzato
, Takuma Higashiura
, Hideki Kanda
, Motonobu Goto^*

^*Corresponding author for this work

Nagoya University
Japan Society for the Promotion of Science
SCF Techno-Link
Kagome Co., Ltd.
Japan Science and Technology Agency

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Production of micro- to nano-sized particles of β-carotene was investigated by means of solution-enhanced dispersion by supercritical fluids (SEDS). β-Carotene was dissolved in dichloromethane (DCM), N,N-dimethylformamide (DMF), n-hexane, or ethyl acetate, and supercritical CO₂ served as an antisolvent. The effects of the organic solvents, operating pressure, and temperature were examined. The morphologies of the particles produced by the SEDS were observed by field emission-scanning electron microscopy and particle sizes were determined by image analysis. Irregularly shaped microparticles were produced in the system with DCM and DMF solution. Plate-like microparticles were generated by using n-hexane solution and irregular nanoparticles by ethyl acetate solution. The optimum operating conditions were found to be ethyl acetate as solvent in a defined pressure and temperature range.

Original language	English
Pages (from-to)	1771-1777
Number of pages	7
Journal	Chemical Engineering and Technology
Volume	39
Issue number	10
DOIs	https://doi.org/10.1002/ceat.201500519
Publication status	Published - 1 Oct 2016

Keywords

Nanoparticle formation
Supercritical CO
Supercritical antisolvent
β-Carotene

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10.1002/ceat.201500519

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title = "Effect of Solvent on Nanoparticle Production of β-Carotene by a Supercritical Antisolvent Process",

abstract = "Production of micro- to nano-sized particles of β-carotene was investigated by means of solution-enhanced dispersion by supercritical fluids (SEDS). β-Carotene was dissolved in dichloromethane (DCM), N,N-dimethylformamide (DMF), n-hexane, or ethyl acetate, and supercritical CO2 served as an antisolvent. The effects of the organic solvents, operating pressure, and temperature were examined. The morphologies of the particles produced by the SEDS were observed by field emission-scanning electron microscopy and particle sizes were determined by image analysis. Irregularly shaped microparticles were produced in the system with DCM and DMF solution. Plate-like microparticles were generated by using n-hexane solution and irregular nanoparticles by ethyl acetate solution. The optimum operating conditions were found to be ethyl acetate as solvent in a defined pressure and temperature range.",

keywords = "Nanoparticle formation, Supercritical CO, Supercritical antisolvent, β-Carotene",

author = "Hazuki Nerome and Siti Machmudah and Wahyudiono and Ryuichi Fukuzato and Takuma Higashiura and Hideki Kanda and Motonobu Goto",

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AU - Nerome, Hazuki

AU - Machmudah, Siti

AU - Wahyudiono,

AU - Fukuzato, Ryuichi

AU - Higashiura, Takuma

AU - Kanda, Hideki

AU - Goto, Motonobu

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Production of micro- to nano-sized particles of β-carotene was investigated by means of solution-enhanced dispersion by supercritical fluids (SEDS). β-Carotene was dissolved in dichloromethane (DCM), N,N-dimethylformamide (DMF), n-hexane, or ethyl acetate, and supercritical CO2 served as an antisolvent. The effects of the organic solvents, operating pressure, and temperature were examined. The morphologies of the particles produced by the SEDS were observed by field emission-scanning electron microscopy and particle sizes were determined by image analysis. Irregularly shaped microparticles were produced in the system with DCM and DMF solution. Plate-like microparticles were generated by using n-hexane solution and irregular nanoparticles by ethyl acetate solution. The optimum operating conditions were found to be ethyl acetate as solvent in a defined pressure and temperature range.

AB - Production of micro- to nano-sized particles of β-carotene was investigated by means of solution-enhanced dispersion by supercritical fluids (SEDS). β-Carotene was dissolved in dichloromethane (DCM), N,N-dimethylformamide (DMF), n-hexane, or ethyl acetate, and supercritical CO2 served as an antisolvent. The effects of the organic solvents, operating pressure, and temperature were examined. The morphologies of the particles produced by the SEDS were observed by field emission-scanning electron microscopy and particle sizes were determined by image analysis. Irregularly shaped microparticles were produced in the system with DCM and DMF solution. Plate-like microparticles were generated by using n-hexane solution and irregular nanoparticles by ethyl acetate solution. The optimum operating conditions were found to be ethyl acetate as solvent in a defined pressure and temperature range.

KW - Nanoparticle formation

KW - Supercritical CO

KW - Supercritical antisolvent

KW - β-Carotene

UR - https://www.scopus.com/pages/publications/84988529996

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SN - 0930-7516

VL - 39

SP - 1771

EP - 1777

JO - Chemical Engineering and Technology

JF - Chemical Engineering and Technology

IS - 10

ER -

Effect of Solvent on Nanoparticle Production of β-Carotene by a Supercritical Antisolvent Process

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Keywords

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