Effect of swimming exercise to cardiac PGC-1 α and HIF-1 α gene expression in mice

Nova Sylviana*, Niswan Helja, Hadaral Hudanul Qolbi, Hanna Goenawan, Ronny Lesmana, Mas Rizky A.A. Syamsunarno, Hasrayati Agustina, Badai Batara Tiksnadi, Imam Megantara, Vita Murniati Tarawan, Setiawan Setiawan, Bethy Hernowo, Unang Supratman, Ambrosius Purba

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Background: Hypoxia caused by exercise condition may alter PGC-1α and HIF-1α expression in cardiac cells. Both factors are transcriptional factors which play a role in conserving energy during metabolic process. However, there is less information about the effects of long term moderate intensity exercise such as swimming on PGC-1α and HIF-1α expression in cardiac cells. Objectives: Aim of this study is to observe the effect of force swimming exercise on the expression PGC-1α and HIF-1α gene expression in cardiac muscle of mice. Methods: Male BALBc mice were divided into two groups (n = 10): control (C) and swimming (ST). ST group was subjected to moderate intensity swimming for 4 weeks, 30 minutes/day for 5 days. Hearts of animal models were preserved for cardiac morphology study using HE staining, PGC-1α and HIF-1α mRNA expression study. Results: We observed that cardiac PGC-1α expression in ST was significantly increased 1.5 fold compared with control group (0.64 vs 0.44; CI = 95%, -0.378 - 0.019; P = 0.035), but expression of HIF-1α was significantly decreased 0.4 times lower than control group (0.35 vs 0.52; CI = 95%, 0.27 - 0.31; P = 0,025). Conclusions: Taken together, ST group increased the expression of PGC-1α but decreased the expression of HIF-1α in mice cardiac muscle in response to chronic hypoxia condition.

Original languageEnglish
Article numbere65079
JournalAsian Journal of Sports Medicine
Issue number4
Publication statusPublished - 1 Jan 2018
Externally publishedYes


  • Cardiac
  • Hif-1α
  • Hypoxia
  • Moderate intensity
  • Pgc-1α
  • Swimming


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