Porous Magnesium-based alloys are biodegradable and promising for use in biomedical applications, especially orthopedics. In this work, porous Mg-Zn alloys are successfully synthesized with Mg, Zn, and ammonium hydrogen carbonate (NH4HCO3) powder. This research reports the preparation of porous magnesium alloys by a powder metallurgy technique using ammonium hydrogen carbonate as a space holder particles. The porosity of Mg-Zn alloys depended on the amount of ammonium hydrogen carbonate and was found to have the negative effect on compressive strength and corrosion behavior. On the other hand, the compressive strength and corrosion resistance can be enhanced by the addition of Zn. However, the compressive strength of the material with 69.92% and 1 weight% Zn was comparable with that of natural bone. Furthermore, according to the results, the porous Mg-Zn alloys could be considered one of the most promising materials for biomedical application.