Enzymatic synthesis of cinnamic acid derivatives

Gia Sheu Lee, Arief Widjaja, Yi Hsu Ju*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

60 Citations (Scopus)


Using Novozym 435 as catalyst, the syntheses of ethyl ferulate (EF) from ferulic acid (4-hydroxy 3-methoxy cinnamic acid) and ethanol, and octyl methoxycinnamate (OMC) from p-methoxycinnamic acid and 2-ethyl hexanol were successfully carried out in this study. A conversion of 87% was obtained within 2 days at 75°C for the synthesis of EF. For the synthesis of OMC at 80°C, 90% conversion can be obtained within 1 day. The use of solvent and high reaction temperature resulted in better conversion for the synthesis of cinnamic acid derivatives. Some cinnamic acid esters could also be obtained with higher conversion and shorter reaction times in comparison to other methods reported in the literature. The enzyme can be reused several times before significant activity loss was observed.

Original languageEnglish
Pages (from-to)581-585
Number of pages5
JournalBiotechnology Letters
Issue number8
Publication statusPublished - Apr 2006
Externally publishedYes


  • Cinnamic acid
  • Ethyl ferulate
  • Ferulic acid
  • Novozym 435
  • Octyl methoxycinnamate


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