TY - JOUR
T1 - Evaluation of dosimetry and radiobiological effect of the treatment planning system in the case of oropharyngeal cancer with intensity modulated radiation therapy (IMRT)
AU - Hanum, Ulfi Qomariyah
AU - Marufah, Asmaul Lutfi
AU - Hariyanto, Aditya Prayugo
AU - Endarko,
N1 - Publisher Copyright:
© 2023 Author(s).
PY - 2023/10/4
Y1 - 2023/10/4
N2 - The biologically based limiting factor in optimizing the radiotherapy planning process allows the establishment of dose distribution by balancing the amount of volume received at different dose levels between the target and organs at risk. In planning treatment, to optimize the dose at the target and minimal to the organs at risk (OARs), it is necessary to have a generalized Equivalent Uniform Dose (gEUD) factor in Treatment Planning System (TPS). This study aims to evaluate the radiobiological effect using the IMRT technique. Normal Tissue Complication Probability (NTCP), Tumor Control Probability (TCP), and Homogeneity Index (HI) in oropharyngeal cancer cases were also investigated. In addition, the aimed study was to compare clinical TPS dose calculation with TPS simulation with PRIMO software. DICOM patient data comes from the Cancer Imaging Archive (TCIA) with the code HNSCC-01-0002. The radiobiological analysis of the probability of normal tissue complications based on NTCP parameters was obtained close to 0% for all OARs, whereas the probability of tumor control was 100%. Meanwhile, the dose distribution homogeneity was almost homogeneous due to the value being close to zero. Similar dose distribution patterns were obtained when the clinical TPS compared to the TPS simulation with PRIMO.
AB - The biologically based limiting factor in optimizing the radiotherapy planning process allows the establishment of dose distribution by balancing the amount of volume received at different dose levels between the target and organs at risk. In planning treatment, to optimize the dose at the target and minimal to the organs at risk (OARs), it is necessary to have a generalized Equivalent Uniform Dose (gEUD) factor in Treatment Planning System (TPS). This study aims to evaluate the radiobiological effect using the IMRT technique. Normal Tissue Complication Probability (NTCP), Tumor Control Probability (TCP), and Homogeneity Index (HI) in oropharyngeal cancer cases were also investigated. In addition, the aimed study was to compare clinical TPS dose calculation with TPS simulation with PRIMO software. DICOM patient data comes from the Cancer Imaging Archive (TCIA) with the code HNSCC-01-0002. The radiobiological analysis of the probability of normal tissue complications based on NTCP parameters was obtained close to 0% for all OARs, whereas the probability of tumor control was 100%. Meanwhile, the dose distribution homogeneity was almost homogeneous due to the value being close to zero. Similar dose distribution patterns were obtained when the clinical TPS compared to the TPS simulation with PRIMO.
KW - Biological
KW - EUD
KW - IMRT
KW - PRIMO
KW - TPS
UR - http://www.scopus.com/inward/record.url?scp=85177581503&partnerID=8YFLogxK
U2 - 10.1063/5.0166500
DO - 10.1063/5.0166500
M3 - Conference article
AN - SCOPUS:85177581503
SN - 0094-243X
VL - 2903
JO - AIP Conference Proceedings
JF - AIP Conference Proceedings
IS - 1
M1 - 080001
T2 - 10th International Basic Science International Conference, BaSIC 2022
Y2 - 13 September 2022 through 14 September 2022
ER -
