The biologically based limiting factor in optimizing the radiotherapy planning process allows the establishment of dose distribution by balancing the amount of volume received at different dose levels between the target and organs at risk. In planning treatment, to optimize the dose at the target and minimal to the organs at risk (OARs), it is necessary to have a generalized Equivalent Uniform Dose (gEUD) factor in Treatment Planning System (TPS). This study aims to evaluate the radiobiological effect using the IMRT technique. Normal Tissue Complication Probability (NTCP), Tumor Control Probability (TCP), and Homogeneity Index (HI) in oropharyngeal cancer cases were also investigated. In addition, the aimed study was to compare clinical TPS dose calculation with TPS simulation with PRIMO software. DICOM patient data comes from the Cancer Imaging Archive (TCIA) with the code HNSCC-01-0002. The radiobiological analysis of the probability of normal tissue complications based on NTCP parameters was obtained close to 0% for all OARs, whereas the probability of tumor control was 100%. Meanwhile, the dose distribution homogeneity was almost homogeneous due to the value being close to zero. Similar dose distribution patterns were obtained when the clinical TPS compared to the TPS simulation with PRIMO.
|AIP Conference Proceedings
|Published - 4 Oct 2023
|10th International Basic Science International Conference, BaSIC 2022 - Hybrid, Malang, Indonesia
Duration: 13 Sept 2022 → 14 Sept 2022