Extraction of Functional Components from Freeze-Dried Angelica furcijuga Leaves Using Supercritical Carbon Dioxide

Yuriko Hoshino, Wahyudiono, Siti Machmudah, Shoji Hirayama, Hideki Kanda, Munehiro Hoshino, Motonobu Goto*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Angelica furcijuga (A. furcijuga), as a material for traditional Chinese medicine, has been widely used in Asian countries, such as China, Korea, and Japan, for several centuries owing to its therapeutic effects. In this study, A. furcijuga leaves were used as starting materials to extract functional substances using supercritical carbon dioxide (SC-CO2) at pressure and temperature ranges of 20-40 MPa and 40-80 °C, respectively. The extraction process was performed in a semibatch-type system with extraction times of 15-120 min. The high-performance liquid chromatography analysis indicated that kaempferol, ferulic acid, ligustilide, and butylidenephthalide as selected functional substances were successfully extracted under these operating conditions. An operating pressure of 30 MPa with an extraction time of 60 min seems to be an appropriate pressure to extract functional components from A. furcijuga leaves. The Hansen solubility parameter values and statistical analysis showed that SC-CO2 with 10% ethanol addition is a feasible tool to isolate these selected functional substances from the A. furcijuga matrix.

Original languageEnglish
Pages (from-to)5104-5111
Number of pages8
JournalACS Omega
Volume7
Issue number6
DOIs
Publication statusPublished - 15 Feb 2022

Fingerprint

Dive into the research topics of 'Extraction of Functional Components from Freeze-Dried Angelica furcijuga Leaves Using Supercritical Carbon Dioxide'. Together they form a unique fingerprint.

Cite this