Fabrication and characterization of silica/Fe2.18Zn0.82O4 nanocomposites

Ahmad Taufiq*, Anindya Bella Monica, Ainun Nikmah, Arif Hidayat, Sunaryono, Nurul Hidayat, Hendra Susanto, Erfan Handoko

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

In this paper, we report the fabrication and characterization of silica/Fe2.18Zn0.82O4 nanocomposites used as doxorubicin anti-cancer drug carrier. Silica/Fe2.18Zn0.82O4 nanocomposites were synthesized by using coprecipitation method followed by tetraethyl-orthosilicate hydrolysis process. The synthesis products were characterized by means of XRD, XRF, FTIR, UV Vis, and SEM. XRD characterization resulted in particle size of 7.14 nm. The presence of Si and Zn in the samples was confirmed from XRF characterization result: 49.2% for Si and 14.1% for Zn. Furthermore, functional groups of FTIR results also detected Si-O-Si bond in the wavelength of 1023 and 1091 cm-1. Based on the analysis of drug loading, silica/Fe2.18Zn0.82O4 nanocomposites had exemplary absorbance for doxorubicin as an anti-cancer drug. The release profile of the drug also showed the possibility of its use in medical application since release kinetic indicated stable drug dose in a relatively long period.

Original languageEnglish
Title of host publicationInternational Conference on Life Science and Technology, ICoLiST 2019
EditorsAhmad Taufiq, Hendra Susanto, Hadi Nur, Muhammad Aziz, Chuang-Rung Chang, Hyohyemi Lee, Markus Diantoro, Nandang Mufti, Nik Ahmad Nizam Nik Malek, I. Ching Wang, Djoko Tjahnono Iskandar, Gereon Elbers, Sunaryono Sunaryono, Siti Zubaidah, Sumari Sumari, Aulanni'am, Asep Bayu Nandiyanto, Indra Wibowo, Adeodatus Yuda Handaya
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735419902
DOIs
Publication statusPublished - 21 Apr 2020
Externally publishedYes
Event2nd International Conference on Life Science and Technology, ICoLiST 2019 - Malang, East Java, Indonesia
Duration: 12 Sept 201913 Sept 2019

Publication series

NameAIP Conference Proceedings
Volume2231
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference2nd International Conference on Life Science and Technology, ICoLiST 2019
Country/TerritoryIndonesia
CityMalang, East Java
Period12/09/1913/09/19

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