Facile Fabrication of Polyelectrolyte Complex Nanoparticles Based on Chitosan – Poly-2-Acrylamido-2-Methylpropane Sulfonic Acid as a Potential Drug Carrier Material

Arie Wibowo*, Agus Jatmiko, Muhammad Bagas Ananda, Systi Adi Rachmawati, Husaini Ardy, Akfiny Hasdi Aimon, Ferry Iskandar

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Polyelectrolyte complexes (PECs) are attractive materials for drug delivery application as they offer simple preparations and high drug-loading efficiency. In this study, a novel method for preparing polyelectrolyte complex nanoparticles using a simple mixing method of chitosan and poly-2-acrylamido-2-methylpropane sulfonic acid (PAMPS) solutions is presented. The effect of chitosan concentrations was examined by fixing the PAMPS concentration at 0.01 %w/v, while chitosan concentrations were varied from 0.01 to 0.05 %w/v. Based on dynamic light scattering (DLS) and zeta sizer results, increasing the chitosan concentration led to increased average PEC particle sizes with broader particle distributions from 249.1 (polydispersity index/PDI 0.13) to 318.2 nm (PDI 0.19) and changed the particle surface charges from -5.85±0.34 to 11.95±0.84 mV. The addition of glutaraldehyde (GA) followed by dialysis eliminated sodium chloride (NaCl) and produced spherical PEC nanoparticles, confirmed via scanning electron microscopy (SEM) results. Among those samples, PECs with a chitosan concentration of 0.01 %w/v are the most promising drug carrier materials due to their negative surface charges, which promote prolonged circulation time in the bloodstream.

Original languageEnglish
Pages (from-to)561-570
Number of pages10
JournalInternational Journal of Technology
Volume12
Issue number3
DOIs
Publication statusPublished - 2021
Externally publishedYes

Keywords

  • Chitosan
  • Drug carrier
  • Glutaraldehyde
  • PAMPS
  • Polyelectrolyte complex

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