Formation of Fine Particles from Curcumin/PVP by the Supercritical Antisolvent Process with a Coaxial Nozzle

Siti Machmudah; Sugeng Winardi; Wahyudiono; Hideki Kanda; Motonobu Goto

doi:10.1021/acsomega.9b04495

Formation of Fine Particles from Curcumin/PVP by the Supercritical Antisolvent Process with a Coaxial Nozzle

Siti Machmudah^*, Sugeng Winardi, Wahyudiono, Hideki Kanda, Motonobu Goto

^*Corresponding author for this work

Nagoya University

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

The production of fine particles via the supercritical carbon dioxide (SC-CO2) antisolvent process was carried out. The experiments were conducted at temperatures of 40-60 °C and pressures of 8-12 MPa with a 15 mL min-1 carbon dioxide (CO2) and 0.5 mL min-1 feed solution flow rate. As a feed solution, the curcumin and the polyvinylpyrrolidone (PVP) powder were dissolved in acetone and ethanol at concentrations of 1.0 mg mL-1 and 2.0-4.0% in weight, respectively. Scanning electron microscopy (SEM) images described that most of the precipitated particle products have spherical morphologies with a size of less than 1 μm. The Fourier transform infrared spectroscopy (FT-IR) spectra exhibited that the curcumin structural properties did not shift after the SC-CO2 antisolvent process. Moreover, the PVP addition in the curcumin particle products can enhance the curcumin dissolution in distilled water significantly.

Original language	English
Pages (from-to)	6705-6714
Number of pages	10
Journal	ACS Omega
Volume	5
Issue number	12
DOIs	https://doi.org/10.1021/acsomega.9b04495
Publication status	Published - 31 Mar 2020

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title = "Formation of Fine Particles from Curcumin/PVP by the Supercritical Antisolvent Process with a Coaxial Nozzle",

abstract = "The production of fine particles via the supercritical carbon dioxide (SC-CO2) antisolvent process was carried out. The experiments were conducted at temperatures of 40-60 °C and pressures of 8-12 MPa with a 15 mL min-1 carbon dioxide (CO2) and 0.5 mL min-1 feed solution flow rate. As a feed solution, the curcumin and the polyvinylpyrrolidone (PVP) powder were dissolved in acetone and ethanol at concentrations of 1.0 mg mL-1 and 2.0-4.0% in weight, respectively. Scanning electron microscopy (SEM) images described that most of the precipitated particle products have spherical morphologies with a size of less than 1 μm. The Fourier transform infrared spectroscopy (FT-IR) spectra exhibited that the curcumin structural properties did not shift after the SC-CO2 antisolvent process. Moreover, the PVP addition in the curcumin particle products can enhance the curcumin dissolution in distilled water significantly.",

author = "Siti Machmudah and Sugeng Winardi and Wahyudiono and Hideki Kanda and Motonobu Goto",

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AU - Machmudah, Siti

AU - Winardi, Sugeng

AU - Wahyudiono,

AU - Kanda, Hideki

AU - Goto, Motonobu

PY - 2020/3/31

Y1 - 2020/3/31

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AB - The production of fine particles via the supercritical carbon dioxide (SC-CO2) antisolvent process was carried out. The experiments were conducted at temperatures of 40-60 °C and pressures of 8-12 MPa with a 15 mL min-1 carbon dioxide (CO2) and 0.5 mL min-1 feed solution flow rate. As a feed solution, the curcumin and the polyvinylpyrrolidone (PVP) powder were dissolved in acetone and ethanol at concentrations of 1.0 mg mL-1 and 2.0-4.0% in weight, respectively. Scanning electron microscopy (SEM) images described that most of the precipitated particle products have spherical morphologies with a size of less than 1 μm. The Fourier transform infrared spectroscopy (FT-IR) spectra exhibited that the curcumin structural properties did not shift after the SC-CO2 antisolvent process. Moreover, the PVP addition in the curcumin particle products can enhance the curcumin dissolution in distilled water significantly.

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Formation of Fine Particles from Curcumin/PVP by the Supercritical Antisolvent Process with a Coaxial Nozzle

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