TY - GEN
T1 - Free radical scavenging activity of Artocarpus champeden extracts
AU - Lulan, Theodore Y.K.
AU - Fatmawati, Sri
AU - Santoso, Mardi
AU - Ersam, Taslim
N1 - Publisher Copyright:
© 2018 Author(s).
PY - 2018/12/14
Y1 - 2018/12/14
N2 - Artocarpus champeden, commonly known as cempedak in Indonesia, belongs to the Moraceae family. In folk medicine, A. champeden is used to treat various diseases such as diabetic, malaria and cancer. This curing ability indicates the active component content in the plant as antioxidant, antidiabetic, antimalarial or anticancer. The present study was attempted to evaluate antioxidant activity present in methanol extract of A. champeden and its fractions. Antioxidant activity of methanol extract of A. champeden, also fraction of n-hexane, methylene chloride and ethyl acetate were assessed by using in-vitro models include DPPH and ABTS. Analysis of total flavonoid and phenolic contents were expressed as Quercetin Equivalent (QE) and Gallic Acid Equivalent (GAE), respectively. UV Spectrophotometer is used to measure the absorbance degression. Methanol extract of A.champeden showed strong DPPH and ABTS antioxidant activity with IC50 35.45 and 7.98 μg/mL, respectively. Methanol extract also showed high flavonoid and phenolic content with 639.83 mg of QE and 43.51 mg of GAE per 100 g of extracts. The antioxidant activity of ethyl acetate fraction is higher than that of the value obtained by n-hexane and methylene chloride fractions for DPPH and ABTS assays with IC50 37.11 and 6.48 μg/mL, respectively. In our results, it has great pharmacological potential with great value of inhibition activity as a potential source of natural antioxidant.
AB - Artocarpus champeden, commonly known as cempedak in Indonesia, belongs to the Moraceae family. In folk medicine, A. champeden is used to treat various diseases such as diabetic, malaria and cancer. This curing ability indicates the active component content in the plant as antioxidant, antidiabetic, antimalarial or anticancer. The present study was attempted to evaluate antioxidant activity present in methanol extract of A. champeden and its fractions. Antioxidant activity of methanol extract of A. champeden, also fraction of n-hexane, methylene chloride and ethyl acetate were assessed by using in-vitro models include DPPH and ABTS. Analysis of total flavonoid and phenolic contents were expressed as Quercetin Equivalent (QE) and Gallic Acid Equivalent (GAE), respectively. UV Spectrophotometer is used to measure the absorbance degression. Methanol extract of A.champeden showed strong DPPH and ABTS antioxidant activity with IC50 35.45 and 7.98 μg/mL, respectively. Methanol extract also showed high flavonoid and phenolic content with 639.83 mg of QE and 43.51 mg of GAE per 100 g of extracts. The antioxidant activity of ethyl acetate fraction is higher than that of the value obtained by n-hexane and methylene chloride fractions for DPPH and ABTS assays with IC50 37.11 and 6.48 μg/mL, respectively. In our results, it has great pharmacological potential with great value of inhibition activity as a potential source of natural antioxidant.
KW - ABTS
KW - Artocarpus champeden
KW - DPPH
KW - antioxidant activity
UR - http://www.scopus.com/inward/record.url?scp=85059032178&partnerID=8YFLogxK
U2 - 10.1063/1.5082460
DO - 10.1063/1.5082460
M3 - Conference contribution
AN - SCOPUS:85059032178
T3 - AIP Conference Proceedings
BT - 3rd International Seminar on Chemistry
A2 - Kurniawan, Fredy
A2 - Kusumawati, Yuly
A2 - Fatmawati, Sri
A2 - Juwono, Hendro
A2 - Purnomo, Adi Setyo
PB - American Institute of Physics Inc.
T2 - 3rd International Seminar on Chemistry: Green Chemistry and Its Role for Sustainability, ISOC 2018
Y2 - 18 July 2018 through 19 July 2018
ER -