Ganoderic acid Df, a new triterpenoid with aldose reductase inhibitory activity from the fruiting body of Ganoderma lucidum

Sri Fatmawati, Kuniyoshi Shimizu, Ryuichiro Kondo*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

66 Citations (Scopus)

Abstract

Ganoderic acid Df, a new lanostane-type triterpenoid, was isolated from the fruiting body of Ganoderma lucidum. Its structure was characterized as 7β, 11β-dihydroxy-3, 15, 23-trioxo-5α-lanosta-8-en-26-oic acid by 1D- and 2D-NMR spectra. This compound exhibited potent human aldose reductase inhibitory activity, with an IC50 of 22.8 μM in vitro. A carboxyl group of this compound's side chain is essential for eliciting inhibitory activity because its methyl ester is much less active.

Original languageEnglish
Pages (from-to)1033-1036
Number of pages4
JournalFitoterapia
Volume81
Issue number8
DOIs
Publication statusPublished - Dec 2010
Externally publishedYes

Keywords

  • Aldose reductase inhibitor
  • Ganoderic acid
  • Ganoderma lucidum

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