Ganoderic acid Df, a new triterpenoid with aldose reductase inhibitory activity from the fruiting body of Ganoderma lucidum

Sri Fatmawati; Kuniyoshi Shimizu; Ryuichiro Kondo

doi:10.1016/j.fitote.2010.06.025

Ganoderic acid Df, a new triterpenoid with aldose reductase inhibitory activity from the fruiting body of Ganoderma lucidum

Sri Fatmawati, Kuniyoshi Shimizu, Ryuichiro Kondo^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

70 Citations (Scopus)

Abstract

Ganoderic acid Df, a new lanostane-type triterpenoid, was isolated from the fruiting body of Ganoderma lucidum. Its structure was characterized as 7β, 11β-dihydroxy-3, 15, 23-trioxo-5α-lanosta-8-en-26-oic acid by 1D- and 2D-NMR spectra. This compound exhibited potent human aldose reductase inhibitory activity, with an IC₅₀ of 22.8 μM in vitro. A carboxyl group of this compound's side chain is essential for eliciting inhibitory activity because its methyl ester is much less active.

Original language	English
Pages (from-to)	1033-1036
Number of pages	4
Journal	Fitoterapia
Volume	81
Issue number	8
DOIs	https://doi.org/10.1016/j.fitote.2010.06.025
Publication status	Published - Dec 2010
Externally published	Yes

Keywords

Aldose reductase inhibitor
Ganoderic acid
Ganoderma lucidum

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10.1016/j.fitote.2010.06.025

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title = "Ganoderic acid Df, a new triterpenoid with aldose reductase inhibitory activity from the fruiting body of Ganoderma lucidum",

abstract = "Ganoderic acid Df, a new lanostane-type triterpenoid, was isolated from the fruiting body of Ganoderma lucidum. Its structure was characterized as 7β, 11β-dihydroxy-3, 15, 23-trioxo-5α-lanosta-8-en-26-oic acid by 1D- and 2D-NMR spectra. This compound exhibited potent human aldose reductase inhibitory activity, with an IC50 of 22.8 μM in vitro. A carboxyl group of this compound's side chain is essential for eliciting inhibitory activity because its methyl ester is much less active.",

keywords = "Aldose reductase inhibitor, Ganoderic acid, Ganoderma lucidum",

author = "Sri Fatmawati and Kuniyoshi Shimizu and Ryuichiro Kondo",

note = "Funding Information: We are thankful to Dr. Miyamoto for optical rotation measurement, to Mr. Matsumoto for HRESIMS measurement and Hitachi Scholarship Foundation - Japan, for postgraduate scholarship to S.F.",

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doi = "10.1016/j.fitote.2010.06.025",

language = "English",

volume = "81",

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T1 - Ganoderic acid Df, a new triterpenoid with aldose reductase inhibitory activity from the fruiting body of Ganoderma lucidum

AU - Fatmawati, Sri

AU - Shimizu, Kuniyoshi

AU - Kondo, Ryuichiro

N1 - Funding Information: We are thankful to Dr. Miyamoto for optical rotation measurement, to Mr. Matsumoto for HRESIMS measurement and Hitachi Scholarship Foundation - Japan, for postgraduate scholarship to S.F.

PY - 2010/12

Y1 - 2010/12

N2 - Ganoderic acid Df, a new lanostane-type triterpenoid, was isolated from the fruiting body of Ganoderma lucidum. Its structure was characterized as 7β, 11β-dihydroxy-3, 15, 23-trioxo-5α-lanosta-8-en-26-oic acid by 1D- and 2D-NMR spectra. This compound exhibited potent human aldose reductase inhibitory activity, with an IC50 of 22.8 μM in vitro. A carboxyl group of this compound's side chain is essential for eliciting inhibitory activity because its methyl ester is much less active.

AB - Ganoderic acid Df, a new lanostane-type triterpenoid, was isolated from the fruiting body of Ganoderma lucidum. Its structure was characterized as 7β, 11β-dihydroxy-3, 15, 23-trioxo-5α-lanosta-8-en-26-oic acid by 1D- and 2D-NMR spectra. This compound exhibited potent human aldose reductase inhibitory activity, with an IC50 of 22.8 μM in vitro. A carboxyl group of this compound's side chain is essential for eliciting inhibitory activity because its methyl ester is much less active.

KW - Aldose reductase inhibitor

KW - Ganoderic acid

KW - Ganoderma lucidum

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DO - 10.1016/j.fitote.2010.06.025

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SN - 0367-326X

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ER -

Ganoderic acid Df, a new triterpenoid with aldose reductase inhibitory activity from the fruiting body of Ganoderma lucidum

Abstract

Keywords

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