Ganoderol B: A potent α-glucosidase inhibitor isolated from the fruiting body of Ganoderma lucidum

Sri Fatmawati; Kuniyoshi Shimizu; Ryuichiro Kondo

doi:10.1016/j.phymed.2011.03.011

Ganoderol B: A potent α-glucosidase inhibitor isolated from the fruiting body of Ganoderma lucidum

Sri Fatmawati, Kuniyoshi Shimizu^*, Ryuichiro Kondo

^*Corresponding author for this work

Kyushu University

Research output: Contribution to journal › Article › peer-review

128 Citations (Scopus)

Abstract

α-Glucosidase inhibitor has considerable potential as a diabetes mellitus type 2 drug because it prevents the digestion of carbohydrates. The search for the constituents reducing α-glucosidase activity led to the finding of active compounds in the fruiting body of Ganoderma lucidum. The CHCl ₃ extract of the fruiting body of G. lucidum was found to show inhibitory activity on α-glucosidase in vitro. The neutral fraction, with an IC ₅₀ of 88.7 μg/ml, had stronger inhibition than a positive control, acarbose, with an IC ₅₀ of 336.7 μg/ml (521.5 μM). The neutral fraction was subjected to silica gel column chromatography and repeated p-HPLC to provide an active compound, (3β,24E)-lanosta-7,9(11),24-trien-3, 26-diol (ganoderol B). It was found to have high α-glucosidase inhibition, with an IC ₅₀ of 48.5 μg/ml (119.8 μM).

Original language	English
Pages (from-to)	1053-1055
Number of pages	3
Journal	Phytomedicine
Volume	18
Issue number	12
DOIs	https://doi.org/10.1016/j.phymed.2011.03.011
Publication status	Published - 15 Sept 2011

Keywords

Ganoderma lucidum
Ganoderol B
Triterpenoid
α-Glucosidase inhibitor

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.phymed.2011.03.011

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title = "Ganoderol B: A potent α-glucosidase inhibitor isolated from the fruiting body of Ganoderma lucidum",

abstract = "α-Glucosidase inhibitor has considerable potential as a diabetes mellitus type 2 drug because it prevents the digestion of carbohydrates. The search for the constituents reducing α-glucosidase activity led to the finding of active compounds in the fruiting body of Ganoderma lucidum. The CHCl 3 extract of the fruiting body of G. lucidum was found to show inhibitory activity on α-glucosidase in vitro. The neutral fraction, with an IC 50 of 88.7 μg/ml, had stronger inhibition than a positive control, acarbose, with an IC 50 of 336.7 μg/ml (521.5 μM). The neutral fraction was subjected to silica gel column chromatography and repeated p-HPLC to provide an active compound, (3β,24E)-lanosta-7,9(11),24-trien-3, 26-diol (ganoderol B). It was found to have high α-glucosidase inhibition, with an IC 50 of 48.5 μg/ml (119.8 μM).",

keywords = "Ganoderma lucidum, Ganoderol B, Triterpenoid, α-Glucosidase inhibitor",

author = "Sri Fatmawati and Kuniyoshi Shimizu and Ryuichiro Kondo",

year = "2011",

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doi = "10.1016/j.phymed.2011.03.011",

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T2 - A potent α-glucosidase inhibitor isolated from the fruiting body of Ganoderma lucidum

AU - Fatmawati, Sri

AU - Shimizu, Kuniyoshi

AU - Kondo, Ryuichiro

PY - 2011/9/15

Y1 - 2011/9/15

N2 - α-Glucosidase inhibitor has considerable potential as a diabetes mellitus type 2 drug because it prevents the digestion of carbohydrates. The search for the constituents reducing α-glucosidase activity led to the finding of active compounds in the fruiting body of Ganoderma lucidum. The CHCl 3 extract of the fruiting body of G. lucidum was found to show inhibitory activity on α-glucosidase in vitro. The neutral fraction, with an IC 50 of 88.7 μg/ml, had stronger inhibition than a positive control, acarbose, with an IC 50 of 336.7 μg/ml (521.5 μM). The neutral fraction was subjected to silica gel column chromatography and repeated p-HPLC to provide an active compound, (3β,24E)-lanosta-7,9(11),24-trien-3, 26-diol (ganoderol B). It was found to have high α-glucosidase inhibition, with an IC 50 of 48.5 μg/ml (119.8 μM).

AB - α-Glucosidase inhibitor has considerable potential as a diabetes mellitus type 2 drug because it prevents the digestion of carbohydrates. The search for the constituents reducing α-glucosidase activity led to the finding of active compounds in the fruiting body of Ganoderma lucidum. The CHCl 3 extract of the fruiting body of G. lucidum was found to show inhibitory activity on α-glucosidase in vitro. The neutral fraction, with an IC 50 of 88.7 μg/ml, had stronger inhibition than a positive control, acarbose, with an IC 50 of 336.7 μg/ml (521.5 μM). The neutral fraction was subjected to silica gel column chromatography and repeated p-HPLC to provide an active compound, (3β,24E)-lanosta-7,9(11),24-trien-3, 26-diol (ganoderol B). It was found to have high α-glucosidase inhibition, with an IC 50 of 48.5 μg/ml (119.8 μM).

KW - Ganoderma lucidum

KW - Ganoderol B

KW - Triterpenoid

KW - α-Glucosidase inhibitor

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SN - 0944-7113

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JF - Phytomedicine

IS - 12

ER -

Ganoderol B: A potent α-glucosidase inhibitor isolated from the fruiting body of Ganoderma lucidum

Abstract

Keywords

UN SDGs

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