Gold nanoparticles in nonenzymatic electrochemical detection of sugars

Fredy Kurniawan*, Vessela Tsakova, Vladimir M. Mirsky

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

131 Citations (Scopus)


A nonenzymatic electrochemical sensor for detection of sugars was prepared by layer-by-layer deposition of gold nanoparticles on thin gold electrodes. The deposition was optimized by using of surface plasmon resonance. Voltammetric investigation and impedance spectroscopy of the sensor was performed. Electrical currents caused by glucose on bare gold electrodes and on gold electrodes coated by immobilized gold nanoparticles were compared. The electrodes with nanoparticles display much higher current of glucose oxidation. The oxidation becomes blocked when the swept electrode potential exceeded +0.25 V, during the back scan an oxidation peak is observed again but at less positive potential. The magnitudes of these current peaks are linearly dependent on the glucose concentration; this dependence can be used as calibration for analytical applications. The limit of detection for glucose is below 0.5 mM, the sensitivity (normalized to the macroscopic electrode surface) is about 160 μA cm-2 mM-1. The sensor response is linear till at least 8 mM of glucose concentration.

Original languageEnglish
Pages (from-to)1937-1942
Number of pages6
Issue number19-20
Publication statusPublished - Oct 2006
Externally publishedYes


  • Electrochemical
  • Glucose detection
  • Gold nanoparticles


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