TY - JOUR
T1 - Hydrophobic modification of cellulose nanocrystals from bamboo shoots using rarasaponins
AU - Wijaya, Christian J.
AU - Ismadji, Suryadi
AU - Aparamarta, Hakun W.
AU - Gunawan, Setiyo
N1 - Publisher Copyright:
Copyright © 2020 American Chemical Society.
PY - 2020/8/25
Y1 - 2020/8/25
N2 - Because of their hydrophilic tendencies, the modification of cellulose nanocrystals (CNCs) is needed for applying them as a hydrophobic drug carrier. Previous studies have investigated several modification agents, such as cetyltrimethylammonium bromide. Natural surfactants, such as rarasaponins (RSs), are suitable to avoid human health and environmental issues. In this work, RSs were attached onto CNCs from bamboo shoots to enhance their hydrophobicity. The initial RS concentration and the operating temperature were studied to obtain the best conditions for the modification process, which had significances (p-value < 5%) toward the amount of RSs linked on the CNCs (q) as the response. A q as high as 203.81 ± 0.98 mg/g was obtained at an initial RS concentration of 2000 mg/L and an operating temperature of 30 °C. The curcumin uptake on CNCs-RSs reached 12.40 ± 0.24%, while it was slowly released until approximately 78% in 3 days.
AB - Because of their hydrophilic tendencies, the modification of cellulose nanocrystals (CNCs) is needed for applying them as a hydrophobic drug carrier. Previous studies have investigated several modification agents, such as cetyltrimethylammonium bromide. Natural surfactants, such as rarasaponins (RSs), are suitable to avoid human health and environmental issues. In this work, RSs were attached onto CNCs from bamboo shoots to enhance their hydrophobicity. The initial RS concentration and the operating temperature were studied to obtain the best conditions for the modification process, which had significances (p-value < 5%) toward the amount of RSs linked on the CNCs (q) as the response. A q as high as 203.81 ± 0.98 mg/g was obtained at an initial RS concentration of 2000 mg/L and an operating temperature of 30 °C. The curcumin uptake on CNCs-RSs reached 12.40 ± 0.24%, while it was slowly released until approximately 78% in 3 days.
UR - http://www.scopus.com/inward/record.url?scp=85090988875&partnerID=8YFLogxK
U2 - 10.1021/acsomega.0c02425
DO - 10.1021/acsomega.0c02425
M3 - Article
AN - SCOPUS:85090988875
SN - 2470-1343
VL - 5
SP - 20967
EP - 20975
JO - ACS Omega
JF - ACS Omega
IS - 33
ER -
