Because of their hydrophilic tendencies, the modification of cellulose nanocrystals (CNCs) is needed for applying them as a hydrophobic drug carrier. Previous studies have investigated several modification agents, such as cetyltrimethylammonium bromide. Natural surfactants, such as rarasaponins (RSs), are suitable to avoid human health and environmental issues. In this work, RSs were attached onto CNCs from bamboo shoots to enhance their hydrophobicity. The initial RS concentration and the operating temperature were studied to obtain the best conditions for the modification process, which had significances (p-value < 5%) toward the amount of RSs linked on the CNCs (q) as the response. A q as high as 203.81 ± 0.98 mg/g was obtained at an initial RS concentration of 2000 mg/L and an operating temperature of 30 °C. The curcumin uptake on CNCs-RSs reached 12.40 ± 0.24%, while it was slowly released until approximately 78% in 3 days.

Original languageEnglish
Pages (from-to)20967-20975
Number of pages9
JournalACS Omega
Issue number33
Publication statusPublished - 25 Aug 2020


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