TY - JOUR
T1 - Improving the dissolution properties of curcumin using dense gas antisolvent technology
AU - Kurniawansyah, Firman
AU - Quachie, Lisa
AU - Mammucari, Raffaella
AU - Foster, Neil R.
N1 - Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2017/4/15
Y1 - 2017/4/15
N2 - The dissolution properties of curcumin are notoriously poor and hinder its bioavailability. To improve its dissolution properties, curcumin has been formulated with methyl-β-cyclodextrin and polyvinylpyrrolidone by the atomized rapid injection solvent extraction (ARISE) system. The compounds were co-precipitated from organic solutions using carbon dioxide at 30 °C and 95 bar as the antisolvent. Curcumin formulations were also produced by physical mixing and freeze drying for comparative purposes. The morphology, crystallinity, solid state molecular interactions, apparent solubility and dissolution profiles of samples were observed. The results indicate that the ARISE process is effective in the preparation of curcumin micro-composites with enhanced dissolution profiles compared to unprocessed material and products from physical mixing and freeze drying.
AB - The dissolution properties of curcumin are notoriously poor and hinder its bioavailability. To improve its dissolution properties, curcumin has been formulated with methyl-β-cyclodextrin and polyvinylpyrrolidone by the atomized rapid injection solvent extraction (ARISE) system. The compounds were co-precipitated from organic solutions using carbon dioxide at 30 °C and 95 bar as the antisolvent. Curcumin formulations were also produced by physical mixing and freeze drying for comparative purposes. The morphology, crystallinity, solid state molecular interactions, apparent solubility and dissolution profiles of samples were observed. The results indicate that the ARISE process is effective in the preparation of curcumin micro-composites with enhanced dissolution profiles compared to unprocessed material and products from physical mixing and freeze drying.
KW - CO
KW - Curcumin
KW - Dense gas
KW - Dissolution
KW - Micronization
UR - http://www.scopus.com/inward/record.url?scp=85013829785&partnerID=8YFLogxK
U2 - 10.1016/j.ijpharm.2017.02.018
DO - 10.1016/j.ijpharm.2017.02.018
M3 - Article
C2 - 28185959
AN - SCOPUS:85013829785
SN - 0378-5173
VL - 521
SP - 239
EP - 248
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
IS - 1-2
ER -