Improving the dissolution properties of curcumin using dense gas antisolvent technology

Firman Kurniawansyah; Lisa Quachie; Raffaella Mammucari; Neil R. Foster

doi:10.1016/j.ijpharm.2017.02.018

Improving the dissolution properties of curcumin using dense gas antisolvent technology

Firman Kurniawansyah, Lisa Quachie, Raffaella Mammucari, Neil R. Foster^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

The dissolution properties of curcumin are notoriously poor and hinder its bioavailability. To improve its dissolution properties, curcumin has been formulated with methyl-β-cyclodextrin and polyvinylpyrrolidone by the atomized rapid injection solvent extraction (ARISE) system. The compounds were co-precipitated from organic solutions using carbon dioxide at 30 °C and 95 bar as the antisolvent. Curcumin formulations were also produced by physical mixing and freeze drying for comparative purposes. The morphology, crystallinity, solid state molecular interactions, apparent solubility and dissolution profiles of samples were observed. The results indicate that the ARISE process is effective in the preparation of curcumin micro-composites with enhanced dissolution profiles compared to unprocessed material and products from physical mixing and freeze drying.

Original language	English
Pages (from-to)	239-248
Number of pages	10
Journal	International Journal of Pharmaceutics
Volume	521
Issue number	1-2
DOIs	https://doi.org/10.1016/j.ijpharm.2017.02.018
Publication status	Published - 15 Apr 2017

Keywords

CO
Curcumin
Dense gas
Dissolution
Micronization

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10.1016/j.ijpharm.2017.02.018

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title = "Improving the dissolution properties of curcumin using dense gas antisolvent technology",

abstract = "The dissolution properties of curcumin are notoriously poor and hinder its bioavailability. To improve its dissolution properties, curcumin has been formulated with methyl-β-cyclodextrin and polyvinylpyrrolidone by the atomized rapid injection solvent extraction (ARISE) system. The compounds were co-precipitated from organic solutions using carbon dioxide at 30 °C and 95 bar as the antisolvent. Curcumin formulations were also produced by physical mixing and freeze drying for comparative purposes. The morphology, crystallinity, solid state molecular interactions, apparent solubility and dissolution profiles of samples were observed. The results indicate that the ARISE process is effective in the preparation of curcumin micro-composites with enhanced dissolution profiles compared to unprocessed material and products from physical mixing and freeze drying.",

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AU - Kurniawansyah, Firman

AU - Quachie, Lisa

AU - Mammucari, Raffaella

AU - Foster, Neil R.

PY - 2017/4/15

Y1 - 2017/4/15

N2 - The dissolution properties of curcumin are notoriously poor and hinder its bioavailability. To improve its dissolution properties, curcumin has been formulated with methyl-β-cyclodextrin and polyvinylpyrrolidone by the atomized rapid injection solvent extraction (ARISE) system. The compounds were co-precipitated from organic solutions using carbon dioxide at 30 °C and 95 bar as the antisolvent. Curcumin formulations were also produced by physical mixing and freeze drying for comparative purposes. The morphology, crystallinity, solid state molecular interactions, apparent solubility and dissolution profiles of samples were observed. The results indicate that the ARISE process is effective in the preparation of curcumin micro-composites with enhanced dissolution profiles compared to unprocessed material and products from physical mixing and freeze drying.

AB - The dissolution properties of curcumin are notoriously poor and hinder its bioavailability. To improve its dissolution properties, curcumin has been formulated with methyl-β-cyclodextrin and polyvinylpyrrolidone by the atomized rapid injection solvent extraction (ARISE) system. The compounds were co-precipitated from organic solutions using carbon dioxide at 30 °C and 95 bar as the antisolvent. Curcumin formulations were also produced by physical mixing and freeze drying for comparative purposes. The morphology, crystallinity, solid state molecular interactions, apparent solubility and dissolution profiles of samples were observed. The results indicate that the ARISE process is effective in the preparation of curcumin micro-composites with enhanced dissolution profiles compared to unprocessed material and products from physical mixing and freeze drying.

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KW - Dense gas

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KW - Micronization

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Improving the dissolution properties of curcumin using dense gas antisolvent technology

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Keywords

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