Increased risk of pre-eclampsia (PE) among women with the history of migraine

The Objective of this study was to assess possible association of history of migraine with pre-eclampsia (PE). This was a retrospective study to compare history of migraine in 90 women affected by PE with 90 women without PE as the control group. They recruited by a nonrandomized consecutive sampling method. Data were collected by a questionnaire including demographic, medical, obstetrics, and migraine assessment sections. Data were analyzed using SPSS. Results showed an increased risk of PE in women with history of migraine (odds ratio: 2.87; p < 0.05). Result demonstrated that migraine history in the case group is 144 and in control group is 56. Gestational age (GA) at delivery and weight of neonate (WN) were significantly lower compared to control (GA: 37.3 ± 2.6 vs. 38.7± 1.3 weeks T test; P < 0.01) (WN: 2930 ± 690 vs. 3330 ± 420; T test; P < 0.0). Cesarean section was more frequent in the PE group compared to the control group [37 (42) vs. 14 (15.6)]; chi square; p < 0.01]. The association of migraine with PE is the result of some similar mechanism leading to endothelial dysfunction. Frequent reports of an association between migraine and PE in different populations suggest a history of migraine as a risk factor for PEgestational hypertension (GH).