Inhalable curcumin formulations by supercritical technology

Firman Kurniawansyah, Raffaella Mammucari*, Neil R. Foster

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

Inhalable dry formulations for pulmonary delivery of curcumin have been produced by supercritical antisolvent micronization. The antioxidant curcumin was co-processed with hydroxypropyl-beta-cyclodextrin (HP-β-CD) and polyvinylpyrrolidone (PVP) to form binary and ternary composites with enhanced flow-ability for pulmonary delivery. The micronization process adopted was the atomized rapid injection solvent extraction (ARISE) system, and was operated at 95. bar and at temperatures of 25. °C and 40. °C. The products were evaluated in terms of morphology, composition, crystallinity and aerodynamic particle size distributions. A synergistic effect of the excipients on the aerodynamic properties of micronized curcumin formulations has been found. The fine particle fraction (FPF) of curcumin in ARISE-processed powders was as high as 61% in ternary systems, whilst untreated curcumin had a FPF of 10% and micronized binary systems had FPF below 40%. The process produced yields of about 80%, demonstrating significant potential for further development of curcumin formulations for pulmonary administration.

Original languageEnglish
Pages (from-to)289-298
Number of pages10
JournalPowder Technology
Volume284
DOIs
Publication statusPublished - 1 Nov 2015
Externally publishedYes

Keywords

  • ARISE
  • Curcumin
  • HP-β-CD
  • PVP
  • Pulmonary
  • Supercritical

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