Inhibition of aldose reductase in vitro by constituents of Ganoderma lucidum

Sri Fatmawati; Kuniyoshi Shimizu; Ryuichiro Kondo

doi:10.1055/s-0030-1249782

Inhibition of aldose reductase in vitro by constituents of Ganoderma lucidum

Sri Fatmawati, Kuniyoshi Shimizu, Ryuichiro Kondo^*

^*Corresponding author for this work

Kyushu University

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

CHCl₃ extract of the fruiting body of Ganoderma lucidum was found to show inhibitory activity on human aldose reductase in vitro. From the acidic fraction, potent human aldose reductase inhibitors, ganoderic acid C2 (1) and ganoderenic acid A (2), were isolated together with three related compounds. It was found that the free carboxyl group of ganoderic acid C2 and ganoderenic acid A is essential in eliciting the inhibitory activity considering the much lower activity of their methyl esters.

Original language	English
Pages (from-to)	1691-1693
Number of pages	3
Journal	Planta Medica
Volume	76
Issue number	15
DOIs	https://doi.org/10.1055/s-0030-1249782
Publication status	Published - 2010

Keywords

Ganoderma lucidum
Ganodermataceae
aldose reductase inhibitor
ganoderic acid
triterpenoid

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10.1055/s-0030-1249782

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abstract = "CHCl3 extract of the fruiting body of Ganoderma lucidum was found to show inhibitory activity on human aldose reductase in vitro. From the acidic fraction, potent human aldose reductase inhibitors, ganoderic acid C2 (1) and ganoderenic acid A (2), were isolated together with three related compounds. It was found that the free carboxyl group of ganoderic acid C2 and ganoderenic acid A is essential in eliciting the inhibitory activity considering the much lower activity of their methyl esters.",

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author = "Sri Fatmawati and Kuniyoshi Shimizu and Ryuichiro Kondo",

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T1 - Inhibition of aldose reductase in vitro by constituents of Ganoderma lucidum

AU - Fatmawati, Sri

AU - Shimizu, Kuniyoshi

AU - Kondo, Ryuichiro

PY - 2010

Y1 - 2010

N2 - CHCl3 extract of the fruiting body of Ganoderma lucidum was found to show inhibitory activity on human aldose reductase in vitro. From the acidic fraction, potent human aldose reductase inhibitors, ganoderic acid C2 (1) and ganoderenic acid A (2), were isolated together with three related compounds. It was found that the free carboxyl group of ganoderic acid C2 and ganoderenic acid A is essential in eliciting the inhibitory activity considering the much lower activity of their methyl esters.

AB - CHCl3 extract of the fruiting body of Ganoderma lucidum was found to show inhibitory activity on human aldose reductase in vitro. From the acidic fraction, potent human aldose reductase inhibitors, ganoderic acid C2 (1) and ganoderenic acid A (2), were isolated together with three related compounds. It was found that the free carboxyl group of ganoderic acid C2 and ganoderenic acid A is essential in eliciting the inhibitory activity considering the much lower activity of their methyl esters.

KW - Ganoderma lucidum

KW - Ganodermataceae

KW - aldose reductase inhibitor

KW - ganoderic acid

KW - triterpenoid

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DO - 10.1055/s-0030-1249782

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VL - 76

SP - 1691

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JO - Planta Medica

JF - Planta Medica

IS - 15

ER -

Inhibition of aldose reductase in vitro by constituents of Ganoderma lucidum

Abstract

Keywords

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