@inproceedings{d35d088af03b4355b4af135d1da5bbfe,
title = "Ketoprofen-β-cyclodextrin inclusion complexes formation by supercritical process technology",
abstract = "Ketoprofen was a poorly soluble which anti-inflammatory, analgesic and antipyretic drug, solubility of which can be enchanced by form complexation with β-cyclodextrin. Besides that, the inclusion complex reduces the incidence of gastrointestinal side effect of drug. The aims of this research are to study the effect of H2O concentration in the supercritical carbondioxide and operation condition in the formation of ketoprofen-β-Cyclodextrin inclusion complex. This research was began by dissolved H2O in supercritical CO2 at 40°C and various saturation pressures. Then, dissolved H2O contacted with (1:5 w/w) ketoprofen-β-Cyclodextrin mixture at 50°C and various operation pressures. It called saturation process. Saturation was done for ±2 hours with agitation process and continued by decompression process. The products were characterized by drug Release, Differential Scanning Calorimetry (DCS) dan Scanning Electron Microscopy (SEM) analyses. The percentage from this work were 76,82%-89,99% for inclusion complexes. The percentage drug release of ketoprofen were 82,83%-88,36% on various inclusion pressure and various inclusion period.",
keywords = "Carbon dioxide, Complex Inclusion, Cyclodextrin, Ketoprofen, Supercritical, water",
author = "Sumarno and Rizki Rahim and Trisanti, {Prida Novarita}",
note = "Publisher Copyright: {\textcopyright} 2017 Author(s).; 3rd International Seminar on Fundamental and Application of Chemical Engineering 2016, ISFAChE 2016 ; Conference date: 01-11-2016 Through 02-11-2016",
year = "2017",
month = may,
day = "24",
doi = "10.1063/1.4982308",
language = "English",
series = "AIP Conference Proceedings",
publisher = "American Institute of Physics Inc.",
editor = "Widiyastuti and Fadlilatul Taufany and Siti Nurkhamidah",
booktitle = "International Seminar on Fundamental and Application of Chemical Engineering 2016, ISFAChE 2016",
}