Metal Oxide (ZnO, TiO2) Layer Affects Sensitivity of Multisample Colorimetric Detection in Microfluidic Paper-based Biosensor

Ruri Agung Wahyuono*, Akbar Anugrah Putra, Dyah Sawitri

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

In this work, a measurement setup for glucose level quantification was developed using the colorimetric method on paper-based microfluidic analytical device (µPAD) platform. Separation of blood glucose was assisted with ZnO and TiO2 layer in the hydrophilic zone while the quantification of glucose concentration employed image processing technique by evaluating the intensity of different color spaces including RGB, HSV, and the gray scale. The analysis was carried out by measuring the color intensity at various glucose concentrations to assess the color space that exhibits the best sensitivity and accuracy for measuring glucose levels and the effect of metal oxide layer to the sensitivity of colorimetric measurement. The validation results show that the TiO2-modified µPAD exhibits an average error of 13.4% which is in accordance with the standard. The addition of TiO2 layer leads to a significant change in the average correlation which increased by 34.5% whilst the addition of ZnO decreases the sensitivity by 56.9%.

Original languageEnglish
Title of host publication2021 International Conference on Advanced Mechatronics, Intelligent Manufacture and Industrial Automation, ICAMIMIA 2021 - Proceeding
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages272-277
Number of pages6
ISBN (Electronic)9781665499699
DOIs
Publication statusPublished - 2021
Event2021 International Conference on Advanced Mechatronics, Intelligent Manufacture and Industrial Automation, ICAMIMIA 2021 - Surabya, Indonesia
Duration: 8 Dec 20219 Dec 2021

Publication series

Name2021 International Conference on Advanced Mechatronics, Intelligent Manufacture and Industrial Automation, ICAMIMIA 2021 - Proceeding

Conference

Conference2021 International Conference on Advanced Mechatronics, Intelligent Manufacture and Industrial Automation, ICAMIMIA 2021
Country/TerritoryIndonesia
CitySurabya
Period8/12/219/12/21

Keywords

  • TiO
  • ZnO
  • hydrophilic zone
  • separation zone
  • µPAD

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