TY - GEN
T1 - Preliminary study of uptake estimation of 99mTc-HMPAO in brain scan using gamma camera
AU - Savitri, D. E.
AU - Evalisa, M.
AU - Nazir, F.
AU - Dwihapsari, Y.
N1 - Publisher Copyright:
© 2021 Author(s).
PY - 2021/3/29
Y1 - 2021/3/29
N2 - Brain scans have been conducted using gamma camera to determine the brain uptake value from anterior-posterior and lateral images and determine the correlation between injection dose, age, and Body Mass Index (BMI) on brain uptake. This study was performed on six volunteers with an average age of 58 ± 1 years old. Brain scans were performed using a dual-headed gamma camera, and the static images were obtained from anterior-posterior and lateral positions. In this study, the radioisotope was Tc99m mixed with Hexamethyl Propyleneamine Oxime (HMPAO) cold kit pharmaceutical. The average injection dose given to volunteers was 13.35 ± 1.59 mCi. Radiopharmaceutical was administered to volunteers through intravenous injection. 99mTc HMPAO inside the body will emit gamma radiation that will be detected by a gamma camera to produce images of the observed organ. The counts were obtained using segmentation of freehand region-of-interest (ROI) to obtain brain uptake value. The results showed that the uptake mean value from the anterior-posterior image was 3.11%, and the lateral image was 3.19%, respectively. The injection dose and age showed a weak correlation with brain uptake value, while BMI showed an inversely moderate correlation with 99mTc HMPAO uptake value.
AB - Brain scans have been conducted using gamma camera to determine the brain uptake value from anterior-posterior and lateral images and determine the correlation between injection dose, age, and Body Mass Index (BMI) on brain uptake. This study was performed on six volunteers with an average age of 58 ± 1 years old. Brain scans were performed using a dual-headed gamma camera, and the static images were obtained from anterior-posterior and lateral positions. In this study, the radioisotope was Tc99m mixed with Hexamethyl Propyleneamine Oxime (HMPAO) cold kit pharmaceutical. The average injection dose given to volunteers was 13.35 ± 1.59 mCi. Radiopharmaceutical was administered to volunteers through intravenous injection. 99mTc HMPAO inside the body will emit gamma radiation that will be detected by a gamma camera to produce images of the observed organ. The counts were obtained using segmentation of freehand region-of-interest (ROI) to obtain brain uptake value. The results showed that the uptake mean value from the anterior-posterior image was 3.11%, and the lateral image was 3.19%, respectively. The injection dose and age showed a weak correlation with brain uptake value, while BMI showed an inversely moderate correlation with 99mTc HMPAO uptake value.
UR - http://www.scopus.com/inward/record.url?scp=85103698793&partnerID=8YFLogxK
U2 - 10.1063/5.0048735
DO - 10.1063/5.0048735
M3 - Conference contribution
AN - SCOPUS:85103698793
T3 - AIP Conference Proceedings
BT - Proceedings of the International Conference and School on Physics in Medicine and Biosystem, ICSPMB 2020
A2 - Lubis, Lukmanda Evan
A2 - Nuzulia, Nur Aisyah
A2 - Hidayati, Nur Rahmah
PB - American Institute of Physics Inc.
T2 - 2020 International Conference and School on Physics in Medicine and Biosystem: Physics Contribution in Medicine and Biomedical Applications, ICSPMB 2020
Y2 - 6 November 2020 through 8 November 2020
ER -