Process development for the enrichment of curcuminoids in the extract of ionic type of NADES

O. Rachmaniah*, M. R. Muhsin, A. P. Widya, M. Rachimoellah

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review

2 Citations (Scopus)

Abstract

Curcuminoids were successfully extracted from Curcuma zeodaria powder with Natural Deep Eutectic Solvents (NADES) as solvent. Ionic types of NADES such choline chloride-citric acid-water (CCCA-H2O = 1:1:18, mole ratio) and choline chloride-malic acid-water (CCMA-H2O = 1:1:18, mole ratio) gave the highest yield of extracted curcuminoids, ca. 0.2700.025 and 0.3550.055 mg/g respectively for CCCA and CCMA. However, the final product of the extracted curcuminoids was mixed in the NADES matrix. Hence, a separation process by means a solidification was mandatory. Isopropanol-n-hexane in both volume and molar ratio, i.e. 1:1, 1:1.5, 1:2, 2:1, and 2.5:1, were observed as a solvent in the solidification process as well as the solubility of curcuminoids in both isopropanol and n-hexane. Unfortunately, both of CCCA-H2O (1:1:18) or CCMA-H2O (1:1:18) and curcuminoids form a homogenous mixture with isopropanol. Therefore, all NADES constituents, i.e. choline chloride, citric acid/malic acid, and water, should be first removed before solidification process. Solubility of curcuminoids in isopropanol and n-hexane was, respectively, 3.2 mg/mL and 0.4 mg/mL at 40 °C. Isopropanol-hexane (1:1.5, v/v) give the highest recovery of curcuminoids, ca. 74.29%, by solidification process.

Original languageEnglish
Article number012005
JournalIOP Conference Series: Materials Science and Engineering
Volume732
Issue number1
DOIs
Publication statusPublished - 28 Jan 2020
Event1st Annual Technology, Applied Science, and Engineering Conference, ATASEC 2019 - Batu, East Java, Indonesia
Duration: 29 Aug 201930 Aug 2019

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