TY - JOUR
T1 - Processing of Pharmaceuticals for Pulmonary Delivery by Supercritical Technology
AU - Kurniawansyah, F.
AU - Mammucari, R.
AU - Foster, N. R.
N1 - Publisher Copyright:
© Published under licence by IOP Publishing Ltd.
PY - 2019
Y1 - 2019
N2 - There are several advantages of using the human pulmonary pathways for drug delivery. These include large absorption area, more rapid onset of therapeutic effect, reduced dose of bioactive delivery and lower side effects of therapy. Inhalable products should meet several criteria, in particular shape, surface roughness and particle size (approximately 1-5 μm, or 2-3 μm as optimum) to reach the deep region of human lungs (alveolus). In an attempt to produce such powders, supercritical fluid (SCF) technology has been proposed as an alternative to high energy consumptive yet popular mechanical methods such as milling. In this article, application of SCF technology for inhalable products manufacturing is briefly overviewed. Discussion focuses on the process development and formulation strategies to obtain improved product properties of specifically designed for pulmonary administration.
AB - There are several advantages of using the human pulmonary pathways for drug delivery. These include large absorption area, more rapid onset of therapeutic effect, reduced dose of bioactive delivery and lower side effects of therapy. Inhalable products should meet several criteria, in particular shape, surface roughness and particle size (approximately 1-5 μm, or 2-3 μm as optimum) to reach the deep region of human lungs (alveolus). In an attempt to produce such powders, supercritical fluid (SCF) technology has been proposed as an alternative to high energy consumptive yet popular mechanical methods such as milling. In this article, application of SCF technology for inhalable products manufacturing is briefly overviewed. Discussion focuses on the process development and formulation strategies to obtain improved product properties of specifically designed for pulmonary administration.
UR - http://www.scopus.com/inward/record.url?scp=85067812801&partnerID=8YFLogxK
U2 - 10.1088/1757-899X/543/1/012012
DO - 10.1088/1757-899X/543/1/012012
M3 - Conference article
AN - SCOPUS:85067812801
SN - 1757-8981
VL - 543
JO - IOP Conference Series: Materials Science and Engineering
JF - IOP Conference Series: Materials Science and Engineering
IS - 1
M1 - 012012
T2 - 1st International Symposium of Indonesian Chemical Engineering, ISIChem 2018
Y2 - 4 October 2018 through 6 October 2018
ER -