Production of morphology-controllable porous hyaluronic acid particles using a spray-drying method

Ferry Iskandar, Asep Bayu Dani Nandiyanto, W. Widiyastuti, Lee Sin Young, Kikuo Okuyama*, Leon Gradon

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

67 Citations (Scopus)


Hyaluronic acid (HA) porous particles with controllable porosity and pore size, ranging from 100 to 300 nm, were successfully prepared using a colloidal templating and spray-drying method. HA powder and polystyrene latex (PSL) particles, which were used as the precursor and templating agent, respectively, were mixed in aqueous solution and spray-dried using a two-fluid nozzle system to produce HA and PSL composite particles. Water was evaporated during spray-drying using heated air with a temperature of 120 °C. This simple process was completed within several seconds. The prepared particles were collected and washed with an organic solvent to dissolve the PSL templating agent. The porosity and pore size of the resulting particles were easily controlled by changing the initial mass ratio of precursor to templating agent, i.e., HA to PSL, and by altering the size of the PSL template particles.

Original languageEnglish
Pages (from-to)1027-1034
Number of pages8
JournalActa Biomaterialia
Issue number4
Publication statusPublished - May 2009
Externally publishedYes


  • Aerodynamic diameter
  • Etching
  • Hyaluronic acid
  • Particle pores
  • Spray-drying method


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