Production of morphology-controllable porous hyaluronic acid particles using a spray-drying method

Ferry Iskandar; Asep Bayu Dani Nandiyanto; W. Widiyastuti; Lee Sin Young; Kikuo Okuyama; Leon Gradon

doi:10.1016/j.actbio.2008.11.016

Production of morphology-controllable porous hyaluronic acid particles using a spray-drying method

Ferry Iskandar, Asep Bayu Dani Nandiyanto, W. Widiyastuti, Lee Sin Young, Kikuo Okuyama^*, Leon Gradon

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

69 Citations (Scopus)

Abstract

Hyaluronic acid (HA) porous particles with controllable porosity and pore size, ranging from 100 to 300 nm, were successfully prepared using a colloidal templating and spray-drying method. HA powder and polystyrene latex (PSL) particles, which were used as the precursor and templating agent, respectively, were mixed in aqueous solution and spray-dried using a two-fluid nozzle system to produce HA and PSL composite particles. Water was evaporated during spray-drying using heated air with a temperature of 120 °C. This simple process was completed within several seconds. The prepared particles were collected and washed with an organic solvent to dissolve the PSL templating agent. The porosity and pore size of the resulting particles were easily controlled by changing the initial mass ratio of precursor to templating agent, i.e., HA to PSL, and by altering the size of the PSL template particles.

Original language	English
Pages (from-to)	1027-1034
Number of pages	8
Journal	Acta Biomaterialia
Volume	5
Issue number	4
DOIs	https://doi.org/10.1016/j.actbio.2008.11.016
Publication status	Published - May 2009
Externally published	Yes

Keywords

Aerodynamic diameter
Etching
Hyaluronic acid
Particle pores
Spray-drying method

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10.1016/j.actbio.2008.11.016

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title = "Production of morphology-controllable porous hyaluronic acid particles using a spray-drying method",

abstract = "Hyaluronic acid (HA) porous particles with controllable porosity and pore size, ranging from 100 to 300 nm, were successfully prepared using a colloidal templating and spray-drying method. HA powder and polystyrene latex (PSL) particles, which were used as the precursor and templating agent, respectively, were mixed in aqueous solution and spray-dried using a two-fluid nozzle system to produce HA and PSL composite particles. Water was evaporated during spray-drying using heated air with a temperature of 120 °C. This simple process was completed within several seconds. The prepared particles were collected and washed with an organic solvent to dissolve the PSL templating agent. The porosity and pore size of the resulting particles were easily controlled by changing the initial mass ratio of precursor to templating agent, i.e., HA to PSL, and by altering the size of the PSL template particles.",

keywords = "Aerodynamic diameter, Etching, Hyaluronic acid, Particle pores, Spray-drying method",

author = "Ferry Iskandar and Nandiyanto, {Asep Bayu Dani} and W. Widiyastuti and Young, {Lee Sin} and Kikuo Okuyama and Leon Gradon",

note = "Funding Information: The scholarships provided by the Japanese Ministry of Education, Science, Sports, and Culture to A.B.D.N. and W.W. are gratefully acknowledged. Special thanks to Yui Kawano for assistance with this research.",

year = "2009",

month = may,

doi = "10.1016/j.actbio.2008.11.016",

language = "English",

volume = "5",

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AU - Iskandar, Ferry

AU - Nandiyanto, Asep Bayu Dani

AU - Widiyastuti, W.

AU - Young, Lee Sin

AU - Okuyama, Kikuo

AU - Gradon, Leon

N1 - Funding Information: The scholarships provided by the Japanese Ministry of Education, Science, Sports, and Culture to A.B.D.N. and W.W. are gratefully acknowledged. Special thanks to Yui Kawano for assistance with this research.

PY - 2009/5

Y1 - 2009/5

N2 - Hyaluronic acid (HA) porous particles with controllable porosity and pore size, ranging from 100 to 300 nm, were successfully prepared using a colloidal templating and spray-drying method. HA powder and polystyrene latex (PSL) particles, which were used as the precursor and templating agent, respectively, were mixed in aqueous solution and spray-dried using a two-fluid nozzle system to produce HA and PSL composite particles. Water was evaporated during spray-drying using heated air with a temperature of 120 °C. This simple process was completed within several seconds. The prepared particles were collected and washed with an organic solvent to dissolve the PSL templating agent. The porosity and pore size of the resulting particles were easily controlled by changing the initial mass ratio of precursor to templating agent, i.e., HA to PSL, and by altering the size of the PSL template particles.

AB - Hyaluronic acid (HA) porous particles with controllable porosity and pore size, ranging from 100 to 300 nm, were successfully prepared using a colloidal templating and spray-drying method. HA powder and polystyrene latex (PSL) particles, which were used as the precursor and templating agent, respectively, were mixed in aqueous solution and spray-dried using a two-fluid nozzle system to produce HA and PSL composite particles. Water was evaporated during spray-drying using heated air with a temperature of 120 °C. This simple process was completed within several seconds. The prepared particles were collected and washed with an organic solvent to dissolve the PSL templating agent. The porosity and pore size of the resulting particles were easily controlled by changing the initial mass ratio of precursor to templating agent, i.e., HA to PSL, and by altering the size of the PSL template particles.

KW - Aerodynamic diameter

KW - Etching

KW - Hyaluronic acid

KW - Particle pores

KW - Spray-drying method

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JO - Acta Biomaterialia

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ER -

Production of morphology-controllable porous hyaluronic acid particles using a spray-drying method

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Keywords

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