Sentulic acid: A cytotoxic ring A-seco triterpenoid from Sandoricum koetjape Merr

Mai Efdi; Masayuki Ninomiya; Erma Suryani; Kaori Tanaka; Sanusi Ibrahim; Kunitomo Watanabe; Mamoru Koketsu

doi:10.1016/j.bmcl.2012.05.043

Sentulic acid: A cytotoxic ring A-seco triterpenoid from Sandoricum koetjape Merr

Mai Efdi^*
, Masayuki Ninomiya
, Erma Suryani
, Kaori Tanaka
, Sanusi Ibrahim
, Kunitomo Watanabe
, Mamoru Koketsu

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

A new ring A-seco triterpenoid, sentulic acid, along with a known oleanane-type triterpenoid, 3-oxoolean-12-en-27-oic acid, were isolated from the Indonesian plant Sandoricum koetjape Merr. Their chemical structures were elucidated by spectroscopic analysis. In addition, the cytotoxic effects of these compounds on human promyelocytic leukemia HL-60 cells were studied. The results of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays and trypan blue dye exclusion tests showed that sentulic acid and 3-oxoolean-12-en-27-oic acid were able to induce cytotoxicity in these cells. Furthermore, morphological examination and DNA fragmentation analysis indicated that these cytotoxic effects were mediated by apoptosis.

Original language	English
Pages (from-to)	4242-4245
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	22
Issue number	13
DOIs	https://doi.org/10.1016/j.bmcl.2012.05.043
Publication status	Published - 1 Jul 2012
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

3-Oxoolean-12-en-27-oic acid
Apoptosis
Human promyelocytic leukemia HL-60 cell
Sandoricum koetjape Merr
Sentulic acid

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10.1016/j.bmcl.2012.05.043

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title = "Sentulic acid: A cytotoxic ring A-seco triterpenoid from Sandoricum koetjape Merr",

abstract = "A new ring A-seco triterpenoid, sentulic acid, along with a known oleanane-type triterpenoid, 3-oxoolean-12-en-27-oic acid, were isolated from the Indonesian plant Sandoricum koetjape Merr. Their chemical structures were elucidated by spectroscopic analysis. In addition, the cytotoxic effects of these compounds on human promyelocytic leukemia HL-60 cells were studied. The results of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays and trypan blue dye exclusion tests showed that sentulic acid and 3-oxoolean-12-en-27-oic acid were able to induce cytotoxicity in these cells. Furthermore, morphological examination and DNA fragmentation analysis indicated that these cytotoxic effects were mediated by apoptosis.",

keywords = "3-Oxoolean-12-en-27-oic acid, Apoptosis, Human promyelocytic leukemia HL-60 cell, Sandoricum koetjape Merr, Sentulic acid",

author = "Mai Efdi and Masayuki Ninomiya and Erma Suryani and Kaori Tanaka and Sanusi Ibrahim and Kunitomo Watanabe and Mamoru Koketsu",

year = "2012",

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doi = "10.1016/j.bmcl.2012.05.043",

language = "English",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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T2 - A cytotoxic ring A-seco triterpenoid from Sandoricum koetjape Merr

AU - Efdi, Mai

AU - Ninomiya, Masayuki

AU - Suryani, Erma

AU - Tanaka, Kaori

AU - Ibrahim, Sanusi

AU - Watanabe, Kunitomo

AU - Koketsu, Mamoru

PY - 2012/7/1

Y1 - 2012/7/1

N2 - A new ring A-seco triterpenoid, sentulic acid, along with a known oleanane-type triterpenoid, 3-oxoolean-12-en-27-oic acid, were isolated from the Indonesian plant Sandoricum koetjape Merr. Their chemical structures were elucidated by spectroscopic analysis. In addition, the cytotoxic effects of these compounds on human promyelocytic leukemia HL-60 cells were studied. The results of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays and trypan blue dye exclusion tests showed that sentulic acid and 3-oxoolean-12-en-27-oic acid were able to induce cytotoxicity in these cells. Furthermore, morphological examination and DNA fragmentation analysis indicated that these cytotoxic effects were mediated by apoptosis.

AB - A new ring A-seco triterpenoid, sentulic acid, along with a known oleanane-type triterpenoid, 3-oxoolean-12-en-27-oic acid, were isolated from the Indonesian plant Sandoricum koetjape Merr. Their chemical structures were elucidated by spectroscopic analysis. In addition, the cytotoxic effects of these compounds on human promyelocytic leukemia HL-60 cells were studied. The results of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays and trypan blue dye exclusion tests showed that sentulic acid and 3-oxoolean-12-en-27-oic acid were able to induce cytotoxicity in these cells. Furthermore, morphological examination and DNA fragmentation analysis indicated that these cytotoxic effects were mediated by apoptosis.

KW - 3-Oxoolean-12-en-27-oic acid

KW - Apoptosis

KW - Human promyelocytic leukemia HL-60 cell

KW - Sandoricum koetjape Merr

KW - Sentulic acid

UR - https://www.scopus.com/pages/publications/84862208900

U2 - 10.1016/j.bmcl.2012.05.043

DO - 10.1016/j.bmcl.2012.05.043

M3 - Article

C2 - 22672802

AN - SCOPUS:84862208900

SN - 0960-894X

VL - 22

SP - 4242

EP - 4245

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 13

ER -

Sentulic acid: A cytotoxic ring A-seco triterpenoid from Sandoricum koetjape Merr

Abstract

UN SDGs

Keywords

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